Down's syndrome: an atheroma-free model? - PubMed (original) (raw)
Down's syndrome: an atheroma-free model?
J C Murdoch et al. Br Med J. 1977.
Abstract
Postmortem examination of five institutionalised patients with Down's syndrome (DS) aged 40-66 years showed a complete absence of atheroma, while a similar number of mental defectives with DS were found to have mild or severe atheroma. Previous investigation of risk factors for atheroma in 70 patients with DS and 70 age-and sex-matched mental defectives living in the same institution showed significantly lower systolic and diastolic blood pressures in the DS group, with the exception of systolic pressure in men under 40. Fasting serum cholesterol and triglyceride concentrations were similar in the two groups, but triglyceride concentrations were significantly lower than in normal people without a history of vascular disease. These unexplained observations may be relevant in further studies of the pathogenesis of atheroma.
Similar articles
- Down's syndrome and atherosclerosis.
Ylä-Herttuala S, Luoma J, Nikkari T, Kivimäki T. Ylä-Herttuala S, et al. Atherosclerosis. 1989 Apr;76(2-3):269-72. doi: 10.1016/0021-9150(89)90110-x. Atherosclerosis. 1989. PMID: 2525042 - Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications.
Anwar AJ, Walker JD, Frier BM. Anwar AJ, et al. Diabet Med. 1998 Feb;15(2):160-3. doi: 10.1002/(SICI)1096-9136(199802)15:2<160::AID-DIA537>3.0.CO;2-J. Diabet Med. 1998. PMID: 9507919 - Testicular seminoma and Down's syndrome.
Roberge D, Souhami L, Laplante M. Roberge D, et al. Can J Urol. 2001 Feb;8(1):1203-6. Can J Urol. 2001. PMID: 11268309 Review. - Pattern of malignant disorders in individuals with Down's syndrome.
Hasle H. Hasle H. Lancet Oncol. 2001 Jul;2(7):429-36. doi: 10.1016/S1470-2045(00)00435-6. Lancet Oncol. 2001. PMID: 11905737 Review.
Cited by
- Understanding the basis for Down syndrome phenotypes.
Roper RJ, Reeves RH. Roper RJ, et al. PLoS Genet. 2006 Mar;2(3):e50. doi: 10.1371/journal.pgen.0020050. PLoS Genet. 2006. PMID: 16596169 Free PMC article. - Risk of Major Cardiovascular Events in People with Down Syndrome.
Sobey CG, Judkins CP, Sundararajan V, Phan TG, Drummond GR, Srikanth VK. Sobey CG, et al. PLoS One. 2015 Sep 30;10(9):e0137093. doi: 10.1371/journal.pone.0137093. eCollection 2015. PLoS One. 2015. PMID: 26421620 Free PMC article. - Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer's Disease.
Pivtoraiko VN, Racic T, Abrahamson EE, Villemagne VL, Handen BL, Lott IT, Head E, Ikonomovic MD. Pivtoraiko VN, et al. Front Aging Neurosci. 2021 Aug 13;13:728739. doi: 10.3389/fnagi.2021.728739. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34489686 Free PMC article. - A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.
Thalman S, Van Pelt KL, Lin AL, Johnson NF, Jicha G, Caban-Holt A, Robertson W, Lightner D, Powell D, Head E, Schmitt F. Thalman S, et al. J Intellect Disabil Res. 2020 Dec;64(12):934-945. doi: 10.1111/jir.12784. Epub 2020 Sep 30. J Intellect Disabil Res. 2020. PMID: 32996650 Free PMC article. - Cardiometabolic Risk and Body Composition in Youth With Down Syndrome.
Magge SN, Zemel BS, Pipan ME, Gidding SS, Kelly A. Magge SN, et al. Pediatrics. 2019 Aug;144(2):e20190137. doi: 10.1542/peds.2019-0137. Epub 2019 Jul 17. Pediatrics. 2019. PMID: 31315916 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources