Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc - PubMed (original) (raw)
Affiliations
- PMID: 1419902
Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc
B C Armstrong et al. Cell Growth Differ. 1992 Jun.
Abstract
The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. We have isolated and characterized complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc, with extensive overlap existing between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis.
Similar articles
- Lack of correlation between N-myc and MAX expression in neuroblastoma tumors and in cell lines: implication for N-myc-MAX complex formation.
Raschella G, Romeo A, Negroni A, Pucci S, Dominici C, Castello MA, Bevilacqua P, Felsani A, Calabretta B. Raschella G, et al. Cancer Res. 1994 Apr 15;54(8):2251-5. Cancer Res. 1994. PMID: 8174135 - N-myc regulation of type I insulin-like growth factor receptor in a human neuroblastoma cell line.
Chambéry D, Mohseni-Zadeh S, de Gallé B, Babajko S. Chambéry D, et al. Cancer Res. 1999 Jun 15;59(12):2898-902. Cancer Res. 1999. PMID: 10383152 - In vivo regulation of single copy and amplified N-myc in human neuroblastoma cells.
Lutz W, Schwab M. Lutz W, et al. Oncogene. 1997 Jul 17;15(3):303-15. doi: 10.1038/sj.onc.1201195. Oncogene. 1997. PMID: 9233765 - Control of c-myc regulation in normal and neoplastic cells.
Spencer CA, Groudine M. Spencer CA, et al. Adv Cancer Res. 1991;56:1-48. doi: 10.1016/s0065-230x(08)60476-5. Adv Cancer Res. 1991. PMID: 2028839 Review. No abstract available.
Cited by
- Super-enhancer MYCNOS-SE promotes chemoresistance in small cell lung cancer by recruiting transcription factors CTCF and KLF15.
Niu Y, Tang Y, Ma F, Zhou X, Chen Y, Wang Y, Xu Y, Sun L, Liang S, Yang J, Wang K, Zhang F, Su S, Guo L. Niu Y, et al. Oncogene. 2024 Nov 8. doi: 10.1038/s41388-024-03202-1. Online ahead of print. Oncogene. 2024. PMID: 39511411 - Molecular insights into the hedgehog signaling pathway correlated non-coding RNAs in acute lymphoblastic leukemia, a bioinformatics study.
Talebi E, Ghoraeian P, Shams Z, Rahimi H. Talebi E, et al. Ann Hematol. 2024 Sep 3. doi: 10.1007/s00277-024-05763-3. Online ahead of print. Ann Hematol. 2024. PMID: 39223285 - Structural characterization of human de novo protein NCYM and its complex with a newly identified DNA aptamer using atomic force microscopy and small-angle X-ray scattering.
Yamamoto S, Kono F, Nakatani K, Hirose M, Horii K, Hippo Y, Tamada T, Suenaga Y, Matsuo T. Yamamoto S, et al. Front Oncol. 2023 Nov 23;13:1213678. doi: 10.3389/fonc.2023.1213678. eCollection 2023. Front Oncol. 2023. PMID: 38074684 Free PMC article. - CD47-Dependent Regulation of Immune Checkpoint Gene Expression and MYCN mRNA Splicing in Murine CD8 and Jurkat T Cells.
Kaur S, Awad D, Finney RP, Meyer TJ, Singh SP, Cam MC, Karim BO, Warner AC, Roberts DD. Kaur S, et al. Int J Mol Sci. 2023 Jan 30;24(3):2612. doi: 10.3390/ijms24032612. Int J Mol Sci. 2023. PMID: 36768931 Free PMC article. - MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and Prognosis to Targeted Treatment.
Bartolucci D, Montemurro L, Raieli S, Lampis S, Pession A, Hrelia P, Tonelli R. Bartolucci D, et al. Cancers (Basel). 2022 Sep 12;14(18):4421. doi: 10.3390/cancers14184421. Cancers (Basel). 2022. PMID: 36139583 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases