THE EFFECTS OF SEVERAL ALCOHOLS ON THE PROPERTIES OF THE SQUID GIANT AXON - PubMed (original) (raw)
THE EFFECTS OF SEVERAL ALCOHOLS ON THE PROPERTIES OF THE SQUID GIANT AXON
C M ARMSTRONG et al. J Gen Physiol. 1964 Nov.
Abstract
The effects of several alcohols on the resting potential, action potential, and voltage-clamp currents of the squid giant axon have been measured. All the alcohols employed are similar in that they depress maximum sodium conductance much more than maximum potassium conductance. Octyl alcohol differs from the others (C(2) through C(5)) in that it has less tendency to depolarize the axon. Depolarization is always accompanied by a decrease of g(K) near the resting potential, such that the ratio g(K)/g(leak) is decreased. Steady-state inactivation of the sodium ion current is unaffected by alcohols, as is membrane capacity. Resting membrane conductance is usually decreased by alcohols. The findings are discussed in relation to work on monomolecular films.
Similar articles
- ANOMALOUS RECTIFICATION IN THE SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE.
ARMSTRONG CM, BINSTOCK L. ARMSTRONG CM, et al. J Gen Physiol. 1965 May;48(5):859-72. doi: 10.1085/jgp.48.5.859. J Gen Physiol. 1965. PMID: 14324992 Free PMC article. - EFFECT OF ETHANOL ON THE SODIUM AND POTASSIUM CONDUCTANCES OF THE SQUID AXON MEMBRANE.
MOORE JW, ULBRICHT W, TAKATA M. MOORE JW, et al. J Gen Physiol. 1964 Nov;48(2):279-95. doi: 10.1085/jgp.48.2.279. J Gen Physiol. 1964. PMID: 14225258 Free PMC article. - EFFECT OF DETERGENT ON ELECTRICAL PROPERTIES OF SQUID AXON MEMBRANE.
KISHIMOTO U, ADELMAN WJ Jr. KISHIMOTO U, et al. J Gen Physiol. 1964 May;47(5):975-86. doi: 10.1085/jgp.47.5.975. J Gen Physiol. 1964. PMID: 14158665 Free PMC article. - ELECTRODIFFUSION MODELS FOR THE MEMBRANE OF SQUID GIANT AXON.
COLE KS. COLE KS. Physiol Rev. 1965 Apr;45:340-79. doi: 10.1152/physrev.1965.45.2.340. Physiol Rev. 1965. PMID: 14302913 Review. No abstract available. - [THE PERFUSED GIANT AXON OF THE SQUID. A NEW METHOD IN NEUROPHYSIOLOGY AND ITS FIRST USES].
MEVES H. MEVES H. Experientia. 1963 Aug 15;19:377-83. doi: 10.1007/BF02171499. Experientia. 1963. PMID: 14084043 Review. German. No abstract available.
Cited by
- Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs.
Lundbaek JA. Lundbaek JA. J Gen Physiol. 2008 May;131(5):421-9. doi: 10.1085/jgp.200709948. Epub 2008 Apr 14. J Gen Physiol. 2008. PMID: 18411332 Free PMC article. No abstract available. - Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol.
Lundbaek JA, Birn P, Hansen AJ, Søgaard R, Nielsen C, Girshman J, Bruno MJ, Tape SE, Egebjerg J, Greathouse DV, Mattice GL, Koeppe RE 2nd, Andersen OS. Lundbaek JA, et al. J Gen Physiol. 2004 May;123(5):599-621. doi: 10.1085/jgp.200308996. J Gen Physiol. 2004. PMID: 15111647 Free PMC article. - ANOMALOUS RECTIFICATION IN THE SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE.
ARMSTRONG CM, BINSTOCK L. ARMSTRONG CM, et al. J Gen Physiol. 1965 May;48(5):859-72. doi: 10.1085/jgp.48.5.859. J Gen Physiol. 1965. PMID: 14324992 Free PMC article. - [Muscle afferent block in the treatment of oromandibular dystonia. Difference in effect between masticatory and lingual muscles].
Yoshida K. Yoshida K. Nervenarzt. 2003 Jun;74(6):516-22. doi: 10.1007/s00115-003-1508-3. Epub 2003 May 13. Nervenarzt. 2003. PMID: 12799790 German. - Time course of TEA(+)-induced anomalous rectification in squid giant axons.
Armstrong CM. Armstrong CM. J Gen Physiol. 1966 Nov;50(2):491-503. doi: 10.1085/jgp.50.2.491. J Gen Physiol. 1966. PMID: 11526842 Free PMC article.
References
- J Physiol. 1962 Nov;164:355-74 - PubMed
- Biophys J. 1960 Nov;1:161-202 - PubMed
- J Gen Physiol. 1960 Sep;44:123-67 - PubMed
- J Physiol. 1959 Oct;148:161-79 - PubMed
- J Physiol. 1952 Apr;116(4):473-96 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous