Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy - PubMed (original) (raw)

Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy

L L Pashko et al. Carcinogenesis. 1992 Oct.

Abstract

Restricting the food intake of laboratory mice and rats markedly reduces the incidence of spontaneous and experimentally induced cancers. Using the two-stage skin tumorigenesis model in CD-1 mice, we report now that food restriction suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of epidermal [3H]thymidine incorporation as well as TPA promotion of skin papillomas, whereas adrenalectomy completely reverses the inhibition in [3H]thymidine incorporation and tumor development. These results suggest that the adrenal gland may play an important role in mediating the tumor inhibitory effect of food restriction.

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