Heterogeneity of Tau proteins during mouse brain development and differentiation of cultured neurons - PubMed (original) (raw)
Heterogeneity of Tau proteins during mouse brain development and differentiation of cultured neurons
J C Larcher et al. Dev Biol. 1992 Nov.
Abstract
Tau microtubule-associated proteins constitute a group of developmentally regulated neuronal proteins. Using the high-resolution two-dimensional polyacrylamide gel electrophoresis system, we have resolved more than 60 distinct Tau isoforms in the adult mouse brain. Tau protein heterogeneity increases drastically during the second week of brain development. In neuronal primary cell cultures, some of these developmental changes can be observed. The increase of Tau heterogeneity in culture is more limited and reaches a plateau after a period corresponding to the second week of development. Most, if not all, of the vast Tau heterogeneity can be attributed to intensive post-translational phosphorylation, which may affect the structure of the proteins.
Similar articles
- Heterogeneity of tau protein and mRNA expression during the development of cerebellar granule cell neurons in vitro.
Przyborski SA, Cambray-Deakin MA. Przyborski SA, et al. Brain Res Dev Brain Res. 1995 Jun 27;87(1):29-45. doi: 10.1016/0165-3806(95)00050-n. Brain Res Dev Brain Res. 1995. PMID: 7554230 - Tau isoform expression and phosphorylation state during differentiation of cultured neuronal cells.
Smith CJ, Anderton BH, Davis DR, Gallo JM. Smith CJ, et al. FEBS Lett. 1995 Nov 20;375(3):243-8. doi: 10.1016/0014-5793(95)01221-y. FEBS Lett. 1995. PMID: 7498509 - Developmental regulation of alternatively spliced isoforms of mRNA encoding MAP2 and tau in rat brain oligodendrocytes during culture maturation.
Richter-Landsberg C, Gorath M. Richter-Landsberg C, et al. J Neurosci Res. 1999 May 1;56(3):259-70. doi: 10.1002/(SICI)1097-4547(19990501)56:3<259::AID-JNR5>3.0.CO;2-N. J Neurosci Res. 1999. PMID: 10336255 - The physiology and pathology of microtubule-associated protein tau.
Wang JZ, Gao X, Wang ZH. Wang JZ, et al. Essays Biochem. 2014;56:111-23. doi: 10.1042/bse0560111. Essays Biochem. 2014. PMID: 25131590 Review. - Tau protein as a differential biomarker of tauopathies.
Sergeant N, Delacourte A, Buée L. Sergeant N, et al. Biochim Biophys Acta. 2005 Jan 3;1739(2-3):179-97. doi: 10.1016/j.bbadis.2004.06.020. Biochim Biophys Acta. 2005. PMID: 15615637 Review.
Cited by
- Influence of phosphorylation on isoform composition and function of a microtubule-associated protein from developing Artemia.
Zhang J, Macrae TH. Zhang J, et al. Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):419-24. doi: 10.1042/bj3070419. Biochem J. 1995. PMID: 7733878 Free PMC article. - L-Ilf3 and L-NF90 traffic to the nucleolus granular component: alternatively-spliced exon 3 encodes a nucleolar localization motif.
Viranaicken W, Gasmi L, Chaumet A, Durieux C, Georget V, Denoulet P, Larcher JC. Viranaicken W, et al. PLoS One. 2011;6(7):e22296. doi: 10.1371/journal.pone.0022296. Epub 2011 Jul 19. PLoS One. 2011. PMID: 21811582 Free PMC article. - Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.
Goode BL, Denis PE, Panda D, Radeke MJ, Miller HP, Wilson L, Feinstein SC. Goode BL, et al. Mol Biol Cell. 1997 Feb;8(2):353-65. doi: 10.1091/mbc.8.2.353. Mol Biol Cell. 1997. PMID: 9190213 Free PMC article. - Biochemical characterization of the mouse muscle-specific enolase: developmental changes in electrophoretic variants and selective binding to other proteins.
Merkulova T, Lucas M, Jabet C, Lamandé N, Rouzeau JD, Gros F, Lazar M, Keller A. Merkulova T, et al. Biochem J. 1997 May 1;323 ( Pt 3)(Pt 3):791-800. doi: 10.1042/bj3230791. Biochem J. 1997. PMID: 9169614 Free PMC article. - Tau-beta-galactosidase, an axon-targeted fusion protein.
Callahan CA, Thomas JB. Callahan CA, et al. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5972-6. doi: 10.1073/pnas.91.13.5972. Proc Natl Acad Sci U S A. 1994. PMID: 8016099 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases