B and T cell leakiness in the scid mouse mutant - PubMed (original) (raw)
Affiliations
- PMID: 1449786
Review
B and T cell leakiness in the scid mouse mutant
M J Bosma. Immunodefic Rev. 1992.
Abstract
Recombination of antigen receptor gene elements (V, D and J) that code for Ig and TCR variable regions is defective in the scid mouse mutant. However, the defect is not absolute. Developing scid lymphocytes occasionally succeed in forming a productive VDJ and VJ rearrangement at two critical loci (e.g., IgH/IgL or TCR beta/TCR alpha), and given the appropriate stimuli, differentiate into clones of functional B or T cells. Scid mice with detectable B and/or T lymphocytes are referred to as leaky. This review considers the nature and possible basis of B and T cell leakiness in scid mice.
Similar articles
- Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints.
Schuler W, Ruetsch NR, Amsler M, Bosma MJ. Schuler W, et al. Eur J Immunol. 1991 Mar;21(3):589-96. doi: 10.1002/eji.1830210309. Eur J Immunol. 1991. PMID: 1849083 - Two ultraviolet tumor-specific suppressor cell clones. One expresses Ig RNA and the other expresses T cell receptor-alpha and -beta RNA.
Kraig E, Kannapell CC, Fischbach K, Zellmer V, Trial J. Kraig E, et al. J Immunol. 1990 Oct 1;145(7):2050-6. J Immunol. 1990. PMID: 2168916 - The SCID mouse mutant: definition, characterization, and potential uses.
Bosma MJ, Carroll AM. Bosma MJ, et al. Annu Rev Immunol. 1991;9:323-50. doi: 10.1146/annurev.iy.09.040191.001543. Annu Rev Immunol. 1991. PMID: 1910681 Review.
Cited by
- Induction of lung fibrosis in the mouse by intratracheal instillation of fluorescein isothiocyanate is not T-cell-dependent.
Christensen PJ, Goodman RE, Pastoriza L, Moore B, Toews GB. Christensen PJ, et al. Am J Pathol. 1999 Nov;155(5):1773-9. doi: 10.1016/S0002-9440(10)65493-4. Am J Pathol. 1999. PMID: 10550334 Free PMC article. - Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.
Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. Gu Y, et al. Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8076-81. doi: 10.1073/pnas.94.15.8076. Proc Natl Acad Sci U S A. 1997. PMID: 9223317 Free PMC article. - Stem Cell-Based Disease Models for Inborn Errors of Immunity.
Zbinden A, Canté-Barrett K, Pike-Overzet K, Staal FJT. Zbinden A, et al. Cells. 2021 Dec 30;11(1):108. doi: 10.3390/cells11010108. Cells. 2021. PMID: 35011669 Free PMC article. Review. - CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL.
Wesche-Soldato DE, Chung CS, Gregory SH, Salazar-Mather TP, Ayala CA, Ayala A. Wesche-Soldato DE, et al. Am J Pathol. 2007 Jul;171(1):87-96. doi: 10.2353/ajpath.2007.061099. Am J Pathol. 2007. PMID: 17591956 Free PMC article. - DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.
Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA. Maser RS, et al. Mol Cell Biol. 2007 Mar;27(6):2253-65. doi: 10.1128/MCB.01354-06. Epub 2006 Dec 4. Mol Cell Biol. 2007. PMID: 17145779 Free PMC article.