Colworth memorial lecture. Pathways for remodelling chromatin - PubMed (original) (raw)
Review
. 2003 Oct;31(Pt 5):893-905.
doi: 10.1042/bst0310893.
Affiliations
- PMID: 14505445
- DOI: 10.1042/bst0310893
Review
Colworth memorial lecture. Pathways for remodelling chromatin
T Owen-Hughes. Biochem Soc Trans. 2003 Oct.
Abstract
The alteration of chromatin structure plays an integral role in gene regulation. One means by which eukaryotes manipulate chromatin structure involves the use of ATP-dependent chromatin-remodelling enzymes. It appears likely that these enzymes play a widespread role in the regulation of many nuclear processes. Recently, significant progress has been made in defining the alterations to chromatin structure that these enzymes generate. The ability to alter nucleosome positioning may be a common feature of all ATP-dependent remodelling enzymes, but the spectrum of positions to which nucleosomes are relocated varies. Mounting evidence supports the ability of remodelling enzymes to translocate along DNA. This provides a means by which they could alter both the twist and writhe of DNA on the surface of nucleosomes, and so accelerate nucleosome repositioning.
Similar articles
- Mechanisms for ATP-dependent chromatin remodelling.
Whitehouse I, Flaus A, Havas K, Owen-Hughes T. Whitehouse I, et al. Biochem Soc Trans. 2000;28(4):376-9. Biochem Soc Trans. 2000. PMID: 10961923 Review. - Chromatin remodeling by RSC involves ATP-dependent DNA translocation.
Saha A, Wittmeyer J, Cairns BR. Saha A, et al. Genes Dev. 2002 Aug 15;16(16):2120-34. doi: 10.1101/gad.995002. Genes Dev. 2002. PMID: 12183366 Free PMC article. - Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler.
Sinha KK, Gross JD, Narlikar GJ. Sinha KK, et al. Science. 2017 Jan 20;355(6322):eaaa3761. doi: 10.1126/science.aaa3761. Science. 2017. PMID: 28104838 Free PMC article. - The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.
Manning BJ, Yusufzai T. Manning BJ, et al. J Biol Chem. 2017 Jul 14;292(28):11927-11936. doi: 10.1074/jbc.M117.779470. Epub 2017 May 21. J Biol Chem. 2017. PMID: 28533432 Free PMC article. - ATP-dependent chromatin remodelling: action and reaction.
Choudhary P, Varga-Weisz P. Choudhary P, et al. Subcell Biochem. 2007;41:29-43. doi: 10.1007/1-4020-5466-1_2. Subcell Biochem. 2007. PMID: 17484122 Review.
Cited by
- Chromatin Remodelers in the 3D Nuclear Compartment.
Magaña-Acosta M, Valadez-Graham V. Magaña-Acosta M, et al. Front Genet. 2020 Nov 3;11:600615. doi: 10.3389/fgene.2020.600615. eCollection 2020. Front Genet. 2020. PMID: 33329746 Free PMC article. Review. - To be or not to be.
Zhang Z, Hessmann E. Zhang Z, et al. Elife. 2018 Jul 17;7:e38967. doi: 10.7554/eLife.38967. Elife. 2018. PMID: 30014853 Free PMC article. - Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription.
Tang L, Nogales E, Ciferri C. Tang L, et al. Prog Biophys Mol Biol. 2010 Jun-Jul;102(2-3):122-8. doi: 10.1016/j.pbiomolbio.2010.05.001. Epub 2010 May 20. Prog Biophys Mol Biol. 2010. PMID: 20493208 Free PMC article. Review. - The logic of chromatin architecture and remodelling at promoters.
Cairns BR. Cairns BR. Nature. 2009 Sep 10;461(7261):193-8. doi: 10.1038/nature08450. Nature. 2009. PMID: 19741699 Review. - H2A.Z-Mediated Genome-Wide Chromatin Specialization.
Eirín-López J, Ausió J. Eirín-López J, et al. Curr Genomics. 2007 Mar;8(1):59-66. doi: 10.2174/138920207780076965. Curr Genomics. 2007. PMID: 18645626 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous