Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia - PubMed (original) (raw)

Comparative Study

. 2003 Oct;160(10):1790-4.

doi: 10.1176/appi.ajp.160.10.1790.

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Comparative Study

Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia

Warrick J Brewer et al. Am J Psychiatry. 2003 Oct.

Abstract

Objective: Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset.

Method: The olfactory identification ability of 81 patients at ultra-high risk for psychosis was examined in relation to that of 31 healthy comparison subjects. Twenty-two of the ultra-high-risk patients (27.2%) later became psychotic, and 12 of these were diagnosed with a schizophrenia spectrum disorder.

Results: There was a significant impairment in olfactory identification ability in the ultra-high-risk group that later developed a schizophrenia spectrum disorder but not in any other group.

Conclusions: These findings suggest that impairment of olfactory identification is a premorbid marker of transition to schizophrenia, but it is not predictive of psychotic illness more generally.

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