Identifying biological themes within lists of genes with EASE - PubMed (original) (raw)

Identifying biological themes within lists of genes with EASE

Douglas A Hosack et al. Genome Biol. 2003.

Abstract

EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data. The biological themes returned by EASE recapitulate manually determined themes in previously published gene lists and are robust to varying methods of normalization, intensity calculation and statistical selection of genes. EASE is a powerful tool for rapidly converting the results of functional genomics studies from 'genes' to 'themes'.

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Figure 1

Figure 1

The EASE user interface is designed for quick annotation and analysis of gene lists. Gene identifiers are pasted into the 'INPUT GENES' section, and the processes of linking to online tools, over-representation analysis or annotation are launched with buttons in the 'EXPLORE' section. Annotation data can be automatically retrieved from the internet and stored into local data files by clicking the 'update with the most recent online data' button.

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