Integrin signaling to the actin cytoskeleton - PubMed (original) (raw)

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Integrin signaling to the actin cytoskeleton

Kris A DeMali et al. Curr Opin Cell Biol. 2003 Oct.

Abstract

Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5)P2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.

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