Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix metalloproteinase-12: a potential role during arteriogenesis - PubMed (original) (raw)
. 2003 Dec;17(15):2281-3.
doi: 10.1096/fj.03-0071fje. Epub 2003 Oct 2.
Affiliations
- PMID: 14525945
- DOI: 10.1096/fj.03-0071fje
Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix metalloproteinase-12: a potential role during arteriogenesis
Marco M Jost et al. FASEB J. 2003 Dec.
Abstract
Granulocyte/macrophage-colony stimulating factor (GM-CSF) and transforming growth factor (TGF)beta1 induce arteriogenesis in a nonischemic model of femoral artery ligation. Moreover, clinical trials demonstrated an improved collateralization after injection of bone marrow cells. In the present study, the expression of arteriogenic factors in bone marrow-derived macrophages (BMDM) was measured to verify the potential of these cells to influence collateral artery growth. GM-CSF induced in BMDM the expression of monocyte chemoattractive protein (MCP)-1, matrix-metalloproteinase (MMP)-12, and arginase-1-the latter also showing a remarkable increase in activity. During in vivo induced arteriogenesis, the accumulation rate of macrophages around proliferating collaterals was significantly increased. We also show that MCP-1 is found to be mainly expressed in the media of the vessel wall, MMP-12 in macrophages of the adventitia, and arginase at both locations. This study provides for the first time a comprehensive analysis of GM-CSF/TGFbeta1-regulated arteriogenic factors in BMDM and supports the hypothesis that arteriogenesis is a multistage mechanism, including monocyte/macrophage adhesion and transmigration, pro-arteriogenic cytokine expression, degradation of connective tissue, and collagen synthesis regulation. Selective modulation of these mechanisms as well as cell-based therapies supplying arteriogenic factors in vivo point toward new strategies to influence collateral artery growth.
Similar articles
- Macrophage lineage phenotypes and osteoclastogenesis--complexity in the control by GM-CSF and TGF-beta.
Lari R, Fleetwood AJ, Kitchener PD, Cook AD, Pavasovic D, Hertzog PJ, Hamilton JA. Lari R, et al. Bone. 2007 Feb;40(2):323-36. doi: 10.1016/j.bone.2006.09.003. Epub 2006 Oct 18. Bone. 2007. PMID: 17055352 - Tissue resident cells play a dominant role in arteriogenesis and concomitant macrophage accumulation.
Khmelewski E, Becker A, Meinertz T, Ito WD. Khmelewski E, et al. Circ Res. 2004 Sep 17;95(6):E56-64. doi: 10.1161/01.RES.0000143013.04985.E7. Epub 2004 Aug 26. Circ Res. 2004. PMID: 15331452 - Increased granulopoiesis after sequential administration of transforming growth factor-beta 1 and granulocyte-macrophage colony-stimulating factor.
Hestdal K, Jacobsen SE, Ruscetti FW, Longo DL, Boone TC, Keller JR. Hestdal K, et al. Exp Hematol. 1993 Jun;21(6):799-805. Exp Hematol. 1993. PMID: 8500577 - Therapeutic angiogenesis for peripheral artery disease: cytokine therapy.
Kuhlmann MT, Klocke R, Nikol S. Kuhlmann MT, et al. Vasa. 2007 Nov;36(4):253-60. doi: 10.1024/0301-1526.36.4.253. Vasa. 2007. PMID: 18357917 Review. - [The molecular bypass: an established method for revascularisation of non-operable PAD patients or merely a future vision].
Herold J, Said S, Braun-Dullaeus R. Herold J, et al. Zentralbl Chir. 2014 Oct;139(5):508-17. doi: 10.1055/s-0033-1350668. Epub 2013 Oct 2. Zentralbl Chir. 2014. PMID: 24089345 Review. German.
Cited by
- Role of microglia/macrophage polarisation in intraocular diseases (Review).
Li H, Li B, Zheng Y. Li H, et al. Int J Mol Med. 2024 May;53(5):45. doi: 10.3892/ijmm.2024.5369. Epub 2024 Mar 29. Int J Mol Med. 2024. PMID: 38551157 Free PMC article. Review. - Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation.
Kuntschar S, Cardamone G, Klann K, Bauer R, Meyer SP, Raue R, Rappl P, Münch C, Brüne B, Schmid T. Kuntschar S, et al. Int J Mol Sci. 2023 Nov 30;24(23):16981. doi: 10.3390/ijms242316981. Int J Mol Sci. 2023. PMID: 38069304 Free PMC article. - Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.
Raftopoulou S, Valadez-Cosmes P, Mihalic ZN, Schicho R, Kargl J. Raftopoulou S, et al. Int J Mol Sci. 2022 Mar 16;23(6):3218. doi: 10.3390/ijms23063218. Int J Mol Sci. 2022. PMID: 35328639 Free PMC article. Review. - Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway.
Boyer S, Lee HJ, Steele N, Zhang L, Sajjakulnukit P, Andren A, Ward MH, Singh R, Basrur V, Zhang Y, Nesvizhskii AI, Pasca di Magliano M, Halbrook CJ, Lyssiotis CA. Boyer S, et al. Elife. 2022 Feb 14;11:e73796. doi: 10.7554/eLife.73796. Elife. 2022. PMID: 35156921 Free PMC article. - Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment.
Su X, Xu Y, Fox GC, Xiang J, Kwakwa KA, Davis JL, Belle JI, Lee WC, Wong WH, Fontana F, Hernandez-Aya LF, Kobayashi T, Tomasson HM, Su J, Bakewell SJ, Stewart SA, Egbulefu C, Karmakar P, Meyer MA, Veis DJ, DeNardo DG, Lanza GM, Achilefu S, Weilbaecher KN. Su X, et al. J Clin Invest. 2021 Oct 15;131(20):e145296. doi: 10.1172/JCI145296. J Clin Invest. 2021. PMID: 34520398 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous