A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification - PubMed (original) (raw)

A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification

Bennett G Novitch et al. Neuron. 2003.

Free article

Abstract

The specification of neuronal fates in the ventral spinal cord depends on the regulation of homeodomain (HD) and basic-helix-loop-helix (bHLH) proteins by Sonic hedgehog (Shh). Most of these transcription factors function as repressors, leaving unresolved the link between inductive signaling pathways and transcriptional activators involved in ventral neuronal specification. We show here that retinoid signaling and the activator functions of retinoid receptors are required to pattern the expression of HD and bHLH proteins and to specify motor neuron identity. We also show that fibroblast growth factors (FGFs) repress progenitor HD protein expression, implying that evasion of FGF signaling and exposure to retinoid and Shh signals are obligate steps in the emergence of ventral neural pattern. Moreover, joint exposure of neural progenitors to retinoids and FGFs suffices to induce motor neuron differentiation in a Shh-independent manner.

PubMed Disclaimer

Similar articles

• FGF signaling controls Shh-dependent oligodendroglial fate specification in the ventral spinal cord.
  Farreny MA, Agius E, Bel-Vialar S, Escalas N, Khouri-Farah N, Soukkarieh C, Danesin C, Pituello F, Cochard P, Soula C. Farreny MA, et al. Neural Dev. 2018 Mar 8;13(1):3. doi: 10.1186/s13064-018-0100-2. Neural Dev. 2018. PMID: 29519242 Free PMC article.
• An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity.
  Nordström U, Maier E, Jessell TM, Edlund T. Nordström U, et al. PLoS Biol. 2006 Jul;4(8):e252. doi: 10.1371/journal.pbio.0040252. PLoS Biol. 2006. PMID: 16895440 Free PMC article.
• Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3.
  Litingtung Y, Chiang C. Litingtung Y, et al. Nat Neurosci. 2000 Oct;3(10):979-85. doi: 10.1038/79916. Nat Neurosci. 2000. PMID: 11017169
• Retinoids run rampant: multiple roles during spinal cord and motor neuron development.
  Appel B, Eisen JS. Appel B, et al. Neuron. 2003 Oct 30;40(3):461-4. doi: 10.1016/s0896-6273(03)00688-3. Neuron. 2003. PMID: 14642271 Review.
• Together at last: bHLH and LIM-HD regulators cooperate to specify motor neurons.
  Allan DW, Thor S. Allan DW, et al. Neuron. 2003 Jun 5;38(5):675-7. doi: 10.1016/s0896-6273(03)00329-5. Neuron. 2003. PMID: 12797950 Review.

Cited by

• Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord.
  Yu K, McGlynn S, Matise MP. Yu K, et al. Development. 2013 Apr;140(7):1594-604. doi: 10.1242/dev.090845. Development. 2013. PMID: 23482494 Free PMC article.
• Transcriptional regulation of flotillins by the extracellularly regulated kinases and retinoid X receptor complexes.
  Banning A, Ockenga W, Finger F, Siebrasse P, Tikkanen R. Banning A, et al. PLoS One. 2012;7(9):e45514. doi: 10.1371/journal.pone.0045514. Epub 2012 Sep 18. PLoS One. 2012. PMID: 23029064 Free PMC article.
• Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling.
  Law KK, Makino S, Mo R, Zhang X, Puviindran V, Hui CC. Law KK, et al. PLoS One. 2012;7(11):e50193. doi: 10.1371/journal.pone.0050193. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23166838 Free PMC article.
• Modeling Movement Disorders via Generation of hiPSC-Derived Motor Neurons.
  Akter M, Ding B. Akter M, et al. Cells. 2022 Nov 27;11(23):3796. doi: 10.3390/cells11233796. Cells. 2022. PMID: 36497056 Free PMC article. Review.
• Role of retinoic acid during forebrain development begins late when Raldh3 generates retinoic acid in the ventral subventricular zone.
  Molotkova N, Molotkov A, Duester G. Molotkova N, et al. Dev Biol. 2007 Mar 15;303(2):601-10. doi: 10.1016/j.ydbio.2006.11.035. Epub 2006 Dec 2. Dev Biol. 2007. PMID: 17207476 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Nature Publishing Group

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Research Materials

  • Addgene Non-profit plasmid repository

• Miscellaneous

  • SciCrunch