A novel, alternative pathway of apoptosis triggered through class II major histocompatibility complex molecules - PubMed (original) (raw)

Review

. 2003 Dec;81(12):757-65.

doi: 10.1007/s00109-003-0489-9. Epub 2003 Oct 9.

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• PMID: 14551703
• DOI: 10.1007/s00109-003-0489-9

Review

A novel, alternative pathway of apoptosis triggered through class II major histocompatibility complex molecules

Zoltan A Nagy et al. J Mol Med (Berl). 2003 Dec.

Abstract

Major histocompatibility complex class II (MHC-II) molecules, in addition to their role of presenting antigen to T lymphocytes, can serve as receptors triggering programmed cell death. MHC-II induced cell death affects activated/tumour transformed cells selectively, and it proceeds without the involvement of caspases, the major proteases of classical apoptosis. Caspase-independent programmed cell death can also be triggered, albeit less effectively, via a series of other cell surface molecules. Here, we discuss the major characteristics, physiological significance, and clinical relevance of caspase-independent apoptotic pathways with particular emphasis on the one induced by MHC-II ligation.

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