B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma - PubMed (original) (raw)
. 2003 Oct 1;63(19):6501-5.
Haidong Dong, Hideto Tamura, Stephen G Voss, Dallas B Flies, Koji Tamada, Diva Salomao, John Cheville, Fumiya Hirano, Wei Lin, Jan L Kasperbauer, Karla V Ballman, Lieping Chen
Affiliations
- PMID: 14559843
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
Scott E Strome et al. Cancer Res. 2003.
Abstract
In this report, we demonstrate that B7-H1, a B7 family molecule implicated in tumor immune evasion, is constitutively expressed on 66% of freshly isolated squamous cell carcinomas of the head and neck (SCCHN). To define the potential impact of tumor-associated B7-H1 on immunotherapy, the B7-H1-negative mouse SCC line, SCCVII, was transfected to express B7-H1. Although all of the animals succumbed to B7-H1/SCCVII tumors even after adoptive T-cell immunotherapy, the infusion of B7-H1 blocking monoclonal antibody with activated T cells cured 60% of animals. These data support B7-H1 blockade as a new approach to enhance the efficacy of T-cell immunotherapy.
Similar articles
- Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Dong H, et al. Nat Med. 2002 Aug;8(8):793-800. doi: 10.1038/nm730. Epub 2002 Jun 24. Nat Med. 2002. PMID: 12091876 - Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimmermann MC, David O, Burow M, Gordon A, Dhurandhar N, Myers L, Berggren R, Hemminki A, Alvarez RD, Emilie D, Curiel DT, Chen L, Zou W. Curiel TJ, et al. Nat Med. 2003 May;9(5):562-7. doi: 10.1038/nm863. Epub 2003 Apr 21. Nat Med. 2003. PMID: 12704383 - B7.1 on human carcinomas: costimulation of T cells and enhanced tumor-induced T-cell death.
Lang S, Atarashi Y, Nishioka Y, Stanson J, Meidenbauer N, Whiteside TL. Lang S, et al. Cell Immunol. 2000 May 1;201(2):132-43. doi: 10.1006/cimm.2000.1651. Cell Immunol. 2000. PMID: 10831322 - Immunoregulatory molecule B7-H1 (CD274) contributes to skin carcinogenesis.
Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M. Cao Y, et al. Cancer Res. 2011 Jul 15;71(14):4737-41. doi: 10.1158/0008-5472.CAN-11-0527. Epub 2011 Jul 5. Cancer Res. 2011. PMID: 21730022 Review. - Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy.
Thompson RH, Dong H, Kwon ED. Thompson RH, et al. Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):709s-715s. doi: 10.1158/1078-0432.CCR-06-1868. Clin Cancer Res. 2007. PMID: 17255298 Review.
Cited by
- Mild hyperthermia upregulates PD-L1 in the tumor microenvironment and enhances antitumor efficacy of PD-L1 blockade in murine squamous cell carcinoma.
Ohta Y, Ichimura N, Yamaguchi S, Ohara G, Yamamoto N, Itoh Y, Yamada K, Nakamura S, Hibi H. Ohta Y, et al. Nagoya J Med Sci. 2024 Aug;86(3):497-506. doi: 10.18999/nagjms.86.3.497. Nagoya J Med Sci. 2024. PMID: 39355357 Free PMC article. - Current State of Melanoma Therapy and Next Steps: Battling Therapeutic Resistance.
Fateeva A, Eddy K, Chen S. Fateeva A, et al. Cancers (Basel). 2024 Apr 19;16(8):1571. doi: 10.3390/cancers16081571. Cancers (Basel). 2024. PMID: 38672652 Free PMC article. Review. - PD-1-mediated inhibition of T cell activation: Mechanisms and strategies for cancer combination immunotherapy.
Liu R, Li HF, Li S. Liu R, et al. Cell Insight. 2024 Feb 23;3(2):100146. doi: 10.1016/j.cellin.2024.100146. eCollection 2024 Apr. Cell Insight. 2024. PMID: 38425643 Free PMC article. Review. - Targeting HDAC6 improves anti-CD47 immunotherapy.
Gracia-Hernandez M, Yende AS, Gajendran N, Alahmadi Z, Li X, Munoz Z, Tan K, Noonepalle S, Shibata M, Villagra A. Gracia-Hernandez M, et al. J Exp Clin Cancer Res. 2024 Feb 27;43(1):60. doi: 10.1186/s13046-024-02982-4. J Exp Clin Cancer Res. 2024. PMID: 38414061 Free PMC article. - Beyond the Barrier: Unraveling the Mechanisms of Immunotherapy Resistance.
Bell HN, Zou W. Bell HN, et al. Annu Rev Immunol. 2024 Jun;42(1):521-550. doi: 10.1146/annurev-immunol-101819-024752. Epub 2024 Jun 14. Annu Rev Immunol. 2024. PMID: 38382538 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Medical
Research Materials