"Search-and-capture" of microtubules through plus-end-binding proteins (+TIPs) - PubMed (original) (raw)
Review
doi: 10.1093/jb/mvg148.
Affiliations
- PMID: 14561716
- DOI: 10.1093/jb/mvg148
Free article
Review
"Search-and-capture" of microtubules through plus-end-binding proteins (+TIPs)
Yuko Mimori-Kiyosue et al. J Biochem. 2003 Sep.
Free article
Abstract
The generation of a polarized microtubule organization is critically important for proper cellular functions, such as cell division, differentiation and migration. Microtubules themselves are highly dynamic structures, and this dynamic property is temporally and spatially regulated within cells, especially at their plus ends. To explain how microtubules set up and make contacts with cellular structures, a "search-and-capture" mechanism has been proposed, in which the microtubule plus ends dynamically search for and capture specific sites, such as mitotic kinetochores and cell cortex. To date, several classes of proteins have been shown to be associated with microtubule plus ends in a wide range of organisms from fungi to humans and to play critical roles in the "search-and-capture" mechanism. In this review, we overview our current understanding of the "plus-end-binding proteins" (+TIPs), including APC (adenomatous polyposis coli) tumor suppressor protein, cytoplasmic linker proteins (CLIPs), CLIP-associating proteins (CLASPs), cytoplasmic dynein/dynactin, and EB1, an APC-interacting protein.
Similar articles
- A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport.
Vaughan PS, Miura P, Henderson M, Byrne B, Vaughan KT. Vaughan PS, et al. J Cell Biol. 2002 Jul 22;158(2):305-19. doi: 10.1083/jcb.200201029. Epub 2002 Jul 15. J Cell Biol. 2002. PMID: 12119357 Free PMC article. - Distinct mechanisms govern the localisation of Drosophila CLIP-190 to unattached kinetochores and microtubule plus-ends.
Dzhindzhev NS, Rogers SL, Vale RD, Ohkura H. Dzhindzhev NS, et al. J Cell Sci. 2005 Aug 15;118(Pt 16):3781-90. doi: 10.1242/jcs.02504. J Cell Sci. 2005. PMID: 16105886 - Force on spindle microtubule minus ends moves chromosomes.
Elting MW, Hueschen CL, Udy DB, Dumont S. Elting MW, et al. J Cell Biol. 2014 Jul 21;206(2):245-56. doi: 10.1083/jcb.201401091. Epub 2014 Jul 14. J Cell Biol. 2014. PMID: 25023517 Free PMC article. - Microtubule plus-end-tracking proteins: mechanisms and functions.
Akhmanova A, Hoogenraad CC. Akhmanova A, et al. Curr Opin Cell Biol. 2005 Feb;17(1):47-54. doi: 10.1016/j.ceb.2004.11.001. Curr Opin Cell Biol. 2005. PMID: 15661518 Review. - Regulators of spindle microtubules and their mechanisms: Living together matters.
Lakshmi RB, Nair VM, Manna TK. Lakshmi RB, et al. IUBMB Life. 2018 Feb;70(2):101-111. doi: 10.1002/iub.1708. Epub 2018 Jan 4. IUBMB Life. 2018. PMID: 29314664 Review.
Cited by
- Characterization of human Ccser2 as a protein tracking the plus-ends of microtubules.
Shirai Y, Okuda T, Oshima K, Nadano D. Shirai Y, et al. BMC Res Notes. 2023 Sep 8;16(1):198. doi: 10.1186/s13104-023-06475-z. BMC Res Notes. 2023. PMID: 37684684 Free PMC article. - Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism.
Salem D, Fecek RJ. Salem D, et al. Transl Psychiatry. 2023 Jun 23;13(1):221. doi: 10.1038/s41398-023-02483-6. Transl Psychiatry. 2023. PMID: 37353479 Free PMC article. Review. - MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.
Laguillo-Diego A, Kiewisz R, Martí-Gómez C, Baum D, Müller-Reichert T, Vernos I. Laguillo-Diego A, et al. Mol Biol Cell. 2023 Jan 1;34(1):ar1. doi: 10.1091/mbc.E22-08-0306-T. Epub 2022 Nov 9. Mol Biol Cell. 2023. PMID: 36350698 Free PMC article. - Optimizing microtubule arrangements for rapid cargo capture.
Mogre SS, Christensen JR, Reck-Peterson SL, Koslover EF. Mogre SS, et al. Biophys J. 2021 Nov 16;120(22):4918-4931. doi: 10.1016/j.bpj.2021.10.020. Epub 2021 Oct 21. Biophys J. 2021. PMID: 34687720 Free PMC article. - Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.
Uchida K, Scarborough EA, Prosser BL. Uchida K, et al. Annu Rev Physiol. 2022 Feb 10;84:257-283. doi: 10.1146/annurev-physiol-062421-040656. Epub 2021 Oct 6. Annu Rev Physiol. 2022. PMID: 34614374 Free PMC article. Review.