Crosstalk between cAMP and Ca2+ signaling in non-excitable cells - PubMed (original) (raw)
Review
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells
Jason I E Bruce et al. Cell Calcium. 2003 Dec.
Abstract
An impressive array of cytosolic calcium ([Ca2+](i)) signals exert control over a broad range of physiological processes. The specificity and fidelity of these [Ca2+](i) signals is encoded by the frequency, amplitude, and sub-cellular localization of the response. It is believed that the distinct characteristics of [Ca2+](i) signals underlies the differential activation of effectors and ultimately cellular events. This "shaping" of [Ca2+](i) signals can be achieved by the influence of additional signaling pathways modulating the molecular machinery responsible for generating [Ca2+](i) signals. There is a particularly rich source of potential sites of crosstalk between the cAMP and the [Ca2+](i) signaling pathways. This review will focus on the predominant molecular loci at which these classical signaling systems interact to impact the spatio-temporal pattern of [Ca2+](i) signaling in non-excitable cells.
Similar articles
- Ca2+ waves require sequential activation of inositol trisphosphate receptors and ryanodine receptors in pancreatic acini.
Leite MF, Burgstahler AD, Nathanson MH. Leite MF, et al. Gastroenterology. 2002 Feb;122(2):415-27. doi: 10.1053/gast.2002.30982. Gastroenterology. 2002. PMID: 11832456 - Receptor-operated Ca2+ signaling and crosstalk in stimulus secretion coupling.
Tsunoda Y. Tsunoda Y. Biochim Biophys Acta. 1993 Oct 29;1154(2):105-56. doi: 10.1016/0304-4157(93)90008-c. Biochim Biophys Acta. 1993. PMID: 8218335 Review. - Modulation of cytosolic calcium signaling by protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors.
Straub SV, Wagner LE 2nd, Bruce JI, Yule DI. Straub SV, et al. Biol Res. 2004;37(4):593-602. doi: 10.4067/s0716-97602004000400013. Biol Res. 2004. PMID: 15709686 Review. - Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria.
Straub SV, Giovannucci DR, Yule DI. Straub SV, et al. J Gen Physiol. 2000 Oct;116(4):547-60. doi: 10.1085/jgp.116.4.547. J Gen Physiol. 2000. PMID: 11004204 Free PMC article. - Local calcium spiking in pancreatic acinar cells.
Petersen OH. Petersen OH. Ciba Found Symp. 1995;188:85-94; discussion 94-103. Ciba Found Symp. 1995. PMID: 7587625 Review.
Cited by
- Ca2+ and cAMP cross-talk in mitochondria.
Di Benedetto G, Pendin D, Greotti E, Pizzo P, Pozzan T. Di Benedetto G, et al. J Physiol. 2014 Jan 15;592(2):305-12. doi: 10.1113/jphysiol.2013.259135. Epub 2013 Jul 15. J Physiol. 2014. PMID: 23858012 Free PMC article. Review. - Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.
Tovey SC, Dedos SG, Rahman T, Taylor EJ, Pantazaka E, Taylor CW. Tovey SC, et al. J Biol Chem. 2010 Apr 23;285(17):12979-89. doi: 10.1074/jbc.M109.096016. Epub 2010 Feb 26. J Biol Chem. 2010. PMID: 20189985 Free PMC article. - cAMP potentiates InsP3-induced Ca2+ release from the endoplasmic reticulum in blowfly salivary glands.
Schmidt R, Baumann O, Walz B. Schmidt R, et al. BMC Physiol. 2008 May 20;8:10. doi: 10.1186/1472-6793-8-10. BMC Physiol. 2008. PMID: 18492257 Free PMC article. - Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.
Tovey SC, Dedos SG, Taylor EJ, Church JE, Taylor CW. Tovey SC, et al. J Cell Biol. 2008 Oct 20;183(2):297-311. doi: 10.1083/jcb.200803172. J Cell Biol. 2008. PMID: 18936250 Free PMC article. - Cyclic AMP accelerates calcium waves in pancreatic acinar cells.
Shah AU, Grant WM, Latif SU, Mannan ZM, Park AJ, Husain SZ. Shah AU, et al. Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1328-34. doi: 10.1152/ajpgi.00440.2007. Epub 2008 Apr 3. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18388188 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- P01 DE 13539/DE/NIDCR NIH HHS/United States
- R01 DE 14756/DE/NIDCR NIH HHS/United States
- R01 DK 54568/DK/NIDDK NIH HHS/United States
- T32 DE 014293/DE/NIDCR NIH HHS/United States
LinkOut - more resources
Full Text Sources
Miscellaneous