Alternative splicing and evolution - PubMed (original) (raw)
Review
. 2003 Nov;25(11):1031-4.
doi: 10.1002/bies.10371.
Affiliations
- PMID: 14579243
- DOI: 10.1002/bies.10371
Review
Alternative splicing and evolution
Stephanie Boue et al. Bioessays. 2003 Nov.
Abstract
Alternative splicing is a critical post-transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms. It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint.
Copyright 2003 Wiley Periodicals, Inc.
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