Cellular proliferation and genetic events involved in the genesis of Burkitt lymphoma (BL) in immune compromised patients - PubMed (original) (raw)
Cellular proliferation and genetic events involved in the genesis of Burkitt lymphoma (BL) in immune compromised patients
L B Ellwein et al. Cancer Genet Cytogenet. 1992 Nov.
Abstract
A mathematical model simulating lymphomagenesis based on the two-hit theory of carcinogenesis is presented by contrasting the biologic variables responsible for a high risk of developing Burkitt lymphoma (BL) in three immunosuppressed groups with that of nonendemic BL. In this model, the pro-B lymphocyte is considered to be the target for BL-specific translocations such as t(8;14). With repeated mitosis, the target cell pool expands in the high-risk individual, and, thereby, the opportunities for a spontaneous translocation to arise are increased. The chromosomal translocation endows the target cell with survival advantages, and, hence, lymphoma develops. Modeling results demonstrate that this increased cell proliferation is sufficient in accounting entirely for the increase in tumor prevalence. Preventing enhanced cellular proliferation by obviating immune deficiency and treating patients with agents that restore immunity or have antiviral and antiproliferative properties prior to conversion from polyclonal B-cell proliferation to monoclonal malignancy could obviate the development of BL.
Similar articles
- Low incidence of MYC/BCL2 double-hit in Burkitt lymphoma.
Yoshida M, Ichikawa A, Miyoshi H, Kiyasu J, Kimura Y, Niino D, Ohshima K. Yoshida M, et al. Pathol Int. 2015 Sep;65(9):486-9. doi: 10.1111/pin.12333. Epub 2015 Jul 16. Pathol Int. 2015. PMID: 26182827 - Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge.
Boerma EG, Siebert R, Kluin PM, Baudis M. Boerma EG, et al. Leukemia. 2009 Feb;23(2):225-34. doi: 10.1038/leu.2008.281. Epub 2008 Oct 16. Leukemia. 2009. PMID: 18923440 Review. - Constitutive activation of oncogenes by chromosomal translocations in B-cell derived tumors.
Klein G. Klein G. AIDS Res. 1986 Dec;2 Suppl 1:S167-76. AIDS Res. 1986. PMID: 3030345 Review. - A recurrent clonally distinct Burkitt lymphoma case highlights genetic key events contributing to oncogenesis.
Penther D, Viailly PJ, Latour S, Etancelin P, Bohers E, Vellemans H, Camus V, Menard AL, Coutant S, Lanic H, Lemasle E, Drieux F, Veresezan L, Ruminy P, Raimbault A, Soulier J, Frebourg T, Tilly H, Jardin F. Penther D, et al. Genes Chromosomes Cancer. 2019 Aug;58(8):595-601. doi: 10.1002/gcc.22743. Epub 2019 Mar 27. Genes Chromosomes Cancer. 2019. PMID: 30779244 Free PMC article. - B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression.
Leucci E, Onnis A, Cocco M, De Falco G, Imperatore F, Giuseppina A, Costanzo V, Cerino G, Mannucci S, Cantisani R, Nyagol J, Mwanda W, Iriso R, Owang M, Schurfeld K, Bellan C, Lazzi S, Leoncini L. Leucci E, et al. Int J Cancer. 2010 Mar 15;126(6):1316-26. doi: 10.1002/ijc.24655. Int J Cancer. 2010. PMID: 19530237
Cited by
- Cell kinetics and cell cycle regulation in lymphomas.
Leoncini L, Lazzi S, Bellan C, Tosi P. Leoncini L, et al. J Clin Pathol. 2002 Sep;55(9):648-55. doi: 10.1136/jcp.55.9.648. J Clin Pathol. 2002. PMID: 12194992 Free PMC article. Review. - Burkitt's lymphoma: new insights into molecular pathogenesis.
Bellan C, Lazzi S, De Falco G, Nyongo A, Giordano A, Leoncini L. Bellan C, et al. J Clin Pathol. 2003 Mar;56(3):188-92. doi: 10.1136/jcp.56.3.188. J Clin Pathol. 2003. PMID: 12610094 Free PMC article. Review. - Genetic alterations of the retinoblastoma-related gene RB2/p130 identify different pathogenetic mechanisms in and among Burkitt's lymphoma subtypes.
Cinti C, Leoncini L, Nyongo A, Ferrari F, Lazzi S, Bellan C, Vatti R, Zamparelli A, Cevenini G, Tosi GM, Claudio PP, Maraldi NM, Tosi P, Giordano A. Cinti C, et al. Am J Pathol. 2000 Mar;156(3):751-60. doi: 10.1016/s0002-9440(10)64941-3. Am J Pathol. 2000. PMID: 10702389 Free PMC article.