Genetic diversity between human metapneumovirus subgroups - PubMed (original) (raw)
Comparative Study
. 2003 Oct 10;315(1):1-9.
doi: 10.1016/s0042-6822(03)00528-2.
Affiliations
- PMID: 14592754
- DOI: 10.1016/s0042-6822(03)00528-2
Free article
Comparative Study
Genetic diversity between human metapneumovirus subgroups
Stéphane Biacchesi et al. Virology. 2003.
Free article
Abstract
Complete consensus nucleotide sequences were determined for human metapneumovirus (HMPV) isolates CAN97-83 and CAN98-75, representing the two proposed genotypes or genetic subgroups of HMPV. The overall level of genome nucleotide sequence identity and aggregate proteome amino acid sequence identity between the two HMPV subgroups were 80 and 90%, respectively, similar to the respective values of 81 and 88% between the two antigenic subgroups of human respiratory syncytial virus (HRSV). The diversity between HMPV subgroups was greatest for the SH and G proteins (59 and 37% identity, respectively), which were even more divergent than their HRSV counterparts (72 and 55% cross-subgroup identity, respectively). It is reasonable to anticipate that the two genetic subgroups of HMPV represent antigenic subgroups approximately comparable to those of HRSV.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources