Postnatal neurodevelopmental disorders: meeting at the synapse? - PubMed (original) (raw)
. 2003 Oct 31;302(5646):826-30.
doi: 10.1126/science.1089071.
Affiliations
- PMID: 14593168
- DOI: 10.1126/science.1089071
Postnatal neurodevelopmental disorders: meeting at the synapse?
Huda Y Zoghbi. Science. 2003.
Abstract
We often think of neurodevelopmental disorders as beginning before birth, and many certainly do. A handful, however, strike many months after birth, following a period of apparently normal growth and development. Autism and Rett syndrome are two such disorders, and here I consider some of their similarities at the phenotypic and pathogenic levels. I propose that both disorders result from disruption of postnatal or experience-dependent synaptic plasticity.
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