Advances in the hereditary spastic paraplegias - PubMed (original) (raw)
Review
Advances in the hereditary spastic paraplegias
John K Fink. Exp Neurol. 2003 Nov.
Abstract
This review summarizes advances in understanding the genetics of the hereditary spastic paraplegias (HSPs), a diverse group of inherited disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity spastic weakness. Twenty HSP loci and nine HSP genes have been discovered. This progress has yielded new insights into the diverse molecular pathogenesis that underlies these clinically similar disorders.
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