Tuning of innate immunity and polarized responses by decoy receptors - PubMed (original) (raw)
Review
. 2003 Oct;132(2):109-15.
doi: 10.1159/000073711.
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- PMID: 14600422
- DOI: 10.1159/000073711
Review
Tuning of innate immunity and polarized responses by decoy receptors
Alberto Mantovani et al. Int Arch Allergy Immunol. 2003 Oct.
Abstract
After the identification of the interleukin (IL)-1 type II receptor as the prototype, decoy receptors have been identified for a number of members of the IL-1/IL-18, TNF, IL-10 and IL-13 receptor families. Moreover, the silent receptor D6 is a promiscuous decoy and scavenger receptor of inflammatory chemokines. The IL-1 decoy receptor is regulated by pro- and anti-inflammatory signals and its levels may serve as a readout of the activation of anti-inflammatory pathways, for instance by glucocorticoid hormones. Decoy receptors represent a strategy to tune inflammatory and polarized adaptive responses.
Copyright 2003 S. Karger AG, Basel
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