The role of metallothionein II in neuronal differentiation and survival - PubMed (original) (raw)
The role of metallothionein II in neuronal differentiation and survival
Lene B Køhler et al. Brain Res. 2003.
Abstract
Metallothionein I and II (MT-I+II) are antioxidant and tissue protective factors. We have previously shown that MT-I+II prevent oxidative stress and apoptotic cell death and are of therapeutic value in brain inflammation. However, MT-I+II are expressed in glia and it remains to be elucidated if MT-I+II can affect neurons directly. It is likely that MT isoforms could be beneficial also during neurodegenerative disorders. In this study, we have examined if MT-II affects survival and neurite extension of dopaminergic and hippocampal neurons. We show for the first time that MT-II treatment can significantly stimulate neurite extension from both dopaminergic and hippocampal neurons. Moreover, MT-II treatment significantly increases survival of dopaminergic neurons exposed to 6-hydroxydopamine (6-OHDA) and protects significantly hippocampal neurons from amyloid beta-peptide-induced neurotoxicity. Accordingly, treatment with MT-II may be of therapeutic value in neurodegenerative disorders.
Similar articles
- Neuroprotective effects of erythropoietin on 6-hydroxydopamine-treated ventral mesencephalic dopamine-rich cultures.
Ganser C, Papazoglou A, Just L, Nikkhah G. Ganser C, et al. Exp Cell Res. 2010 Mar 10;316(5):737-46. doi: 10.1016/j.yexcr.2010.01.001. Epub 2010 Jan 11. Exp Cell Res. 2010. PMID: 20060824 - Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family.
Ambjørn M, Asmussen JW, Lindstam M, Gotfryd K, Jacobsen C, Kiselyov VV, Moestrup SK, Penkowa M, Bock E, Berezin V. Ambjørn M, et al. J Neurochem. 2008 Jan;104(1):21-37. doi: 10.1111/j.1471-4159.2007.05036.x. Epub 2007 Nov 6. J Neurochem. 2008. PMID: 17986228 - Intraneuronal signaling pathways of metallothionein.
Asmussen JW, Von Sperling ML, Penkowa M. Asmussen JW, et al. J Neurosci Res. 2009 Oct;87(13):2926-36. doi: 10.1002/jnr.22118. J Neurosci Res. 2009. PMID: 19405100 - Metallothionein provides zinc-mediated protective effects against methamphetamine toxicity in SK-N-SH cells.
Ajjimaporn A, Swinscoe J, Shavali S, Govitrapong P, Ebadi M. Ajjimaporn A, et al. Brain Res Bull. 2005 Nov 30;67(6):466-75. doi: 10.1016/j.brainresbull.2005.07.012. Epub 2005 Aug 30. Brain Res Bull. 2005. PMID: 16216695
Cited by
- Transcriptome changes in the nucleus of the solitary tract induced by repeated stress, alcohol dependence, or stress-induced drinking in dependent mice.
Grantham EK, Tiwari GR, Ponomareva O, Harris RA, Lopez MF, Becker HC, Mayfield RD. Grantham EK, et al. Neuropharmacology. 2024 Jan 1;242:109768. doi: 10.1016/j.neuropharm.2023.109768. Epub 2023 Oct 20. Neuropharmacology. 2024. PMID: 37865137 Free PMC article. - CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy.
Battis K, Florio JB, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, Müller SJ, Cobo I, Fixsen B, Kim HY, Masliah E, Glass CK, Schlachetzki JCM, Rissman RA, Winkler J, Hoffmann A. Battis K, et al. J Neurosci. 2022 Oct 5;42(40):7673-7688. doi: 10.1523/JNEUROSCI.0417-22.2022. Epub 2022 Sep 6. J Neurosci. 2022. PMID: 36333098 Free PMC article. - Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins.
West AK, Leung JY, Chung RS. West AK, et al. J Biol Inorg Chem. 2011 Oct;16(7):1115-22. doi: 10.1007/s00775-011-0817-4. Epub 2011 Jul 21. J Biol Inorg Chem. 2011. PMID: 21779915 Review. - The Balance between Life and Death of Cells: Roles of Metallothioneins.
Nielsen AE, Bohr A, Penkowa M. Nielsen AE, et al. Biomark Insights. 2007 Feb 7;1:99-111. Biomark Insights. 2007. PMID: 19690641 Free PMC article. - Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice.
Oakley MS, McCutchan TF, Anantharaman V, Ward JM, Faucette L, Erexson C, Mahajan B, Zheng H, Majam V, Aravind L, Kumar S. Oakley MS, et al. Infect Immun. 2008 Oct;76(10):4518-29. doi: 10.1128/IAI.00525-08. Epub 2008 Jul 21. Infect Immun. 2008. PMID: 18644885 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources