The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses - PubMed (original) (raw)
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The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
Giorgio Trinchieri et al. Immunity. 2003 Nov.
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Abstract
Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity (Hamano et al., 2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions.
Comment on
- The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.
Villarino A, Hibbert L, Lieberman L, Wilson E, Mak T, Yoshida H, Kastelein RA, Saris C, Hunter CA. Villarino A, et al. Immunity. 2003 Nov;19(5):645-55. doi: 10.1016/s1074-7613(03)00300-5. Immunity. 2003. PMID: 14614852 - WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production.
Hamano S, Himeno K, Miyazaki Y, Ishii K, Yamanaka A, Takeda A, Zhang M, Hisaeda H, Mak TW, Yoshimura A, Yoshida H. Hamano S, et al. Immunity. 2003 Nov;19(5):657-67. doi: 10.1016/s1074-7613(03)00298-x. Immunity. 2003. PMID: 14614853
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