Inflammatory blockade restores adult hippocampal neurogenesis - PubMed (original) (raw)
. 2003 Dec 5;302(5651):1760-5.
doi: 10.1126/science.1088417. Epub 2003 Nov 13.
Affiliations
- PMID: 14615545
- DOI: 10.1126/science.1088417
Inflammatory blockade restores adult hippocampal neurogenesis
Michelle L Monje et al. Science. 2003.
Abstract
Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation.
Comment in
- Neuroscience. Microglia: the enemy within?
Kempermann G, Neumann H. Kempermann G, et al. Science. 2003 Dec 5;302(5651):1689-90. doi: 10.1126/science.1092864. Science. 2003. PMID: 14657479 No abstract available.
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