Long-range silencing and position effects at telomeres and centromeres: parallels and differences - PubMed (original) (raw)
Review
Long-range silencing and position effects at telomeres and centromeres: parallels and differences
S Perrod et al. Cell Mol Life Sci. 2003 Nov.
Abstract
Most of the human genome is compacted into heterochromatin, a form that encompasses multiple forms of inactive chromatin structure. Transcriptional silencing mechanisms in budding and fission yeasts have provided genetically tractable models for understanding heritably repressed chromatin. These silent domains are typically found in regions of repetitive DNA, that is, either adjacent to centromeres or telomeres or within the tandemly repeated ribosomal DNA array. Here we address the mechanisms of centromeric, telomeric and locus-specific gene silencing, comparing simple and complex animals with yeast. Some aspects are universally shared, such as histone-tail modifications, while others are unique to either centromeres or telomeres. These may reflect roles for heterochromatin in other chromosomal functions, like kinetochore attachment and DNA ends protection.
Similar articles
- Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.
Emre NC, Ingvarsdottir K, Wyce A, Wood A, Krogan NJ, Henry KW, Li K, Marmorstein R, Greenblatt JF, Shilatifard A, Berger SL. Emre NC, et al. Mol Cell. 2005 Feb 18;17(4):585-94. doi: 10.1016/j.molcel.2005.01.007. Mol Cell. 2005. PMID: 15721261 - The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.
Freeman-Cook LL, Sherman JM, Brachmann CB, Allshire RC, Boeke JD, Pillus L. Freeman-Cook LL, et al. Mol Biol Cell. 1999 Oct;10(10):3171-86. doi: 10.1091/mbc.10.10.3171. Mol Biol Cell. 1999. PMID: 10512858 Free PMC article. - cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site.
Partridge JF, Scott KS, Bannister AJ, Kouzarides T, Allshire RC. Partridge JF, et al. Curr Biol. 2002 Oct 1;12(19):1652-60. doi: 10.1016/s0960-9822(02)01177-6. Curr Biol. 2002. PMID: 12361567 - Silent chromatin at the middle and ends: lessons from yeasts.
Bühler M, Gasser SM. Bühler M, et al. EMBO J. 2009 Aug 5;28(15):2149-61. doi: 10.1038/emboj.2009.185. Epub 2009 Jul 23. EMBO J. 2009. PMID: 19629038 Free PMC article. Review. - The role of heterochromatin in centromere function.
Pidoux AL, Allshire RC. Pidoux AL, et al. Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):569-79. doi: 10.1098/rstb.2004.1611. Philos Trans R Soc Lond B Biol Sci. 2005. PMID: 15905142 Free PMC article. Review.
Cited by
- Telomere and subtelomere high polymorphism might contribute to the specificity of homologous recognition and pairing during meiosis in barley in the context of breeding.
Serrano-León IM, Prieto P, Aguilar M. Serrano-León IM, et al. BMC Genomics. 2023 Oct 26;24(1):642. doi: 10.1186/s12864-023-09738-y. BMC Genomics. 2023. PMID: 37884878 Free PMC article. - Telomeres and sirtuins: at the end we meet again.
Amano H, Sahin E. Amano H, et al. Mol Cell Oncol. 2019 Jul 7;6(5):e1632613. doi: 10.1080/23723556.2019.1632613. eCollection 2019. Mol Cell Oncol. 2019. PMID: 31528700 Free PMC article. - Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.
Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Amano H, et al. Cell Metab. 2019 Jun 4;29(6):1274-1290.e9. doi: 10.1016/j.cmet.2019.03.001. Epub 2019 Mar 28. Cell Metab. 2019. PMID: 30930169 Free PMC article. - Histone Modifications and the Maintenance of Telomere Integrity.
Jezek M, Green EM. Jezek M, et al. Cells. 2019 Feb 25;8(2):199. doi: 10.3390/cells8020199. Cells. 2019. PMID: 30823596 Free PMC article. Review. - Chromatin architecture and virulence-related gene expression in eukaryotic microbial pathogens.
Juárez-Reyes A, Castaño I. Juárez-Reyes A, et al. Curr Genet. 2019 Apr;65(2):435-443. doi: 10.1007/s00294-018-0903-z. Epub 2018 Nov 15. Curr Genet. 2019. PMID: 30443783 Review.
References
- Circulation. 2003 Dec 23;108(25):3084-91 - PubMed
- Circulation. 2004 Jun 8;109(22):2807-16 - PubMed
- Circulation. 2004 Sep 21;110(12):1527-34 - PubMed
- Circulation. 2009 Mar 3;119(8):1085-92 - PubMed
- Anesthesiology. 2001 Jul;95(1):250-4 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases