Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event - PubMed (original) (raw)
. 2003 Dec 1;188(11):1618-29.
doi: 10.1086/379724. Epub 2003 Nov 14.
Affiliations
- PMID: 14639531
- DOI: 10.1086/379724
Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event
Thomas W Geisbert et al. J Infect Dis. 2003.
Abstract
Disseminated intravascular coagulation is a prominent manifestation of Ebola virus (EBOV) infection. Here, we report that tissue factor (TF) plays an important role in triggering the hemorrhagic complications that characterize EBOV infections. Analysis of samples obtained from 25 macaques showed increased levels of TF associated with lymphoid macrophages, whereas analysis of peripheral blood-cell RNA showed increased levels of TF transcripts by day 3. Plasma from macaques contained increased numbers of TF-expressing membrane microparticles. Dysregulation of the fibrinolytic system developed during the course of infection, including a rapid decrease in plasma levels of protein C. Infection of primary human monocytes/macrophages (PHMs) was used to further evaluate the role of TF in EBOV infections. Analysis of PHM RNA at 1-48 h showed increased TF transcripts, whereas levels of TF protein were dramatically increased by day 2. Thus, chemotherapeutic strategies aimed at controlling overexpression of TF may ameliorate the effects of EBOV hemorrhagic fever.
Comment in
- Ebola hemorrhagic fever and septic shock.
Bray M, Mahanty S. Bray M, et al. J Infect Dis. 2003 Dec 1;188(11):1613-7. doi: 10.1086/379727. Epub 2003 Nov 14. J Infect Dis. 2003. PMID: 14639530 No abstract available.
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