Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate - PubMed (original) (raw)
. 1992 Dec 11;258(5089):1812-5.
doi: 10.1126/science.1465619.
Affiliations
- PMID: 1465619
- DOI: 10.1126/science.1465619
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate
N L Allbritton et al. Science. 1992.
Abstract
The range of messenger action of a point source of Ca2+ or inositol 1,4,5-trisphosphate (IP3) was determined from measurements of their diffusion coefficients in a cytosolic extract from Xenopus laevis oocytes. The diffusion coefficient (D) of [3H]IP3 injected into an extract was 283 microns 2/s. D for Ca2+ increased from 13 to 65 microns 2/s when the free calcium concentration was raised from about 90 nM to 1 microM. The slow diffusion of Ca2+ in the physiologic concentration range results from its binding to slowly mobile or immobile buffers. The calculated effective ranges of free Ca2+ before it is buffered, buffered Ca2+, and IP3 determined from their diffusion coefficients and lifetimes were 0.1 micron, 5 microns, and 24 microns, respectively. Thus, for a transient point source of messenger in cells smaller than 20 microns, IP3 is a global messenger, whereas Ca2+ acts in restricted domains.
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