Hepatocellular carcinoma in the thalassaemia syndromes - PubMed (original) (raw)

Multicenter Study

doi: 10.1046/j.1365-2141.2003.04732.x.

Gianluca Vergine, Turi Lombardo, Maria Domenica Cappellini, Paolo Cianciulli, Aurelio Maggio, Disma Renda, Maria Eliana Lai, Antonella Mandas, Gianluca Forni, Antonio Piga, Maria Grazia Bisconte

Affiliations

Multicenter Study

Hepatocellular carcinoma in the thalassaemia syndromes

Caterina Borgna-Pignatti et al. Br J Haematol. 2004 Jan.

Abstract

Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 +/- 11 years and the mean serum ferritin was 1764 +/- 1448 microg/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources