An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells - PubMed (original) (raw)
doi: 10.1038/ni1022. Epub 2003 Dec 21.
Affiliations
- PMID: 14691482
- DOI: 10.1038/ni1022
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
Gérard Eberl et al. Nat Immunol. 2004 Jan.
Abstract
Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.
Comment in
- Lymphoid organogenesis: getting the green light from RORgamma(t).
Lipp M, Müller G. Lipp M, et al. Nat Immunol. 2004 Jan;5(1):12-4. doi: 10.1038/ni0104-12. Nat Immunol. 2004. PMID: 14699400 No abstract available.
Similar articles
- Lymphoid organogenesis: getting the green light from RORgamma(t).
Lipp M, Müller G. Lipp M, et al. Nat Immunol. 2004 Jan;5(1):12-4. doi: 10.1038/ni0104-12. Nat Immunol. 2004. PMID: 14699400 No abstract available. - Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.
Schmutz S, Bosco N, Chappaz S, Boyman O, Acha-Orbea H, Ceredig R, Rolink AG, Finke D. Schmutz S, et al. J Immunol. 2009 Aug 15;183(4):2217-21. doi: 10.4049/jimmunol.0802911. Epub 2009 Jul 27. J Immunol. 2009. PMID: 19635901 - Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.
Meier D, Bornmann C, Chappaz S, Schmutz S, Otten LA, Ceredig R, Acha-Orbea H, Finke D. Meier D, et al. Immunity. 2007 May;26(5):643-54. doi: 10.1016/j.immuni.2007.04.009. Immunity. 2007. PMID: 17521585 - Orphan nuclear receptors in T lymphocyte development.
He YW. He YW. J Leukoc Biol. 2002 Sep;72(3):440-6. J Leukoc Biol. 2002. PMID: 12223510 Review. - Organogenesis of lymphoid tissues.
Mebius RE. Mebius RE. Nat Rev Immunol. 2003 Apr;3(4):292-303. doi: 10.1038/nri1054. Nat Rev Immunol. 2003. PMID: 12669020 Review.
Cited by
- Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s.
Bartemes KR, Kita H. Bartemes KR, et al. J Allergy Clin Immunol. 2021 May;147(5):1531-1547. doi: 10.1016/j.jaci.2021.03.015. J Allergy Clin Immunol. 2021. PMID: 33965091 Free PMC article. Review. - Interleukin-22 drives endogenous thymic regeneration in mice.
Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MR. Dudakov JA, et al. Science. 2012 Apr 6;336(6077):91-5. doi: 10.1126/science.1218004. Epub 2012 Mar 1. Science. 2012. PMID: 22383805 Free PMC article. - Colonic patch and colonic SILT development are independent and differentially regulated events.
Baptista AP, Olivier BJ, Goverse G, Greuter M, Knippenberg M, Kusser K, Domingues RG, Veiga-Fernandes H, Luster AD, Lugering A, Randall TD, Cupedo T, Mebius RE. Baptista AP, et al. Mucosal Immunol. 2013 May;6(3):511-21. doi: 10.1038/mi.2012.90. Epub 2012 Sep 19. Mucosal Immunol. 2013. PMID: 22990625 Free PMC article. - Using argument notation to engineer biological simulations with increased confidence.
Alden K, Andrews PS, Polack FA, Veiga-Fernandes H, Coles MC, Timmis J. Alden K, et al. J R Soc Interface. 2015 Mar 6;12(104):20141059. doi: 10.1098/rsif.2014.1059. J R Soc Interface. 2015. PMID: 25589574 Free PMC article. - Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans.
Sahu SN, Lewis J, Patel I, Bozdag S, Lee JH, LeClerc JE, Cinar HN. Sahu SN, et al. PLoS One. 2012;7(5):e38200. doi: 10.1371/journal.pone.0038200. Epub 2012 May 31. PLoS One. 2012. PMID: 22675448 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases