The pleiotropic actions of vitamin D - PubMed (original) (raw)

Review

The pleiotropic actions of vitamin D

Roberto Lin et al. Bioessays. 2004 Jan.

Abstract

General knowledge of the role of vitamin D3 in human physiology has been shaped by its discovery as a preventive agent of nutritional rickets, a defect in bone development due to inadequate uptake of dietary calcium. Studies on the function of the hormonal form of vitamin D3, 1alpha,25-dihydroxyvitamin D3, have been greatly accelerated by the molecular cloning and structural analysis of the vitamin D3 receptor, which is a ligand-activated regulator of gene transcription. Molecular genetic techniques including genomics have helped reveal that 1alpha,25-dihydroxyvitamin D3 can control more than calcium homeostasis. It has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Moreover, accumulating epidemiological and molecular evidence suggests that 1alpha,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon. Here, we survey the most-recent findings and discuss their implications for the potential therapeutic uses of vitamin D analogues.

Copyright 2003 Wiley Periodicals, Inc.

PubMed Disclaimer

Similar articles

• 1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action.
  Nezbedova P, Brtko J. Nezbedova P, et al. Endocr Regul. 2004 Mar;38(1):29-38. Endocr Regul. 2004. PMID: 15147236 Review.
• Applications of the Vitamin D sterol-Vitamin D receptor (VDR) conformational ensemble model.
  Mizwicki MT, Bishop JE, Norman AW. Mizwicki MT, et al. Steroids. 2005 May-Jun;70(5-7):464-71. doi: 10.1016/j.steroids.2005.03.003. Epub 2005 Apr 8. Steroids. 2005. PMID: 15862832
• Vitamin D's role in cell proliferation and differentiation.
  Samuel S, Sitrin MD. Samuel S, et al. Nutr Rev. 2008 Oct;66(10 Suppl 2):S116-24. doi: 10.1111/j.1753-4887.2008.00094.x. Nutr Rev. 2008. PMID: 18844838 Review.
• Vitamin D resistance.
  Bouillon R, Verstuyf A, Mathieu C, Van Cromphaut S, Masuyama R, Dehaes P, Carmeliet G. Bouillon R, et al. Best Pract Res Clin Endocrinol Metab. 2006 Dec;20(4):627-45. doi: 10.1016/j.beem.2006.09.008. Best Pract Res Clin Endocrinol Metab. 2006. PMID: 17161336 Review.
• Structure-based design of a superagonist ligand for the vitamin D nuclear receptor.
  Hourai S, Rodrigues LC, Antony P, Reina-San-Martin B, Ciesielski F, Magnier BC, Schoonjans K, Mouriño A, Rochel N, Moras D. Hourai S, et al. Chem Biol. 2008 Apr;15(4):383-92. doi: 10.1016/j.chembiol.2008.03.016. Chem Biol. 2008. PMID: 18420145

Cited by

• Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.
  Kariuki SN, Maranville JC, Baxter SS, Jeong C, Nakagome S, Hrusch CL, Witonsky DB, Sperling AI, Di Rienzo A. Kariuki SN, et al. PLoS One. 2016 Jul 25;11(7):e0159779. doi: 10.1371/journal.pone.0159779. eCollection 2016. PLoS One. 2016. PMID: 27454520 Free PMC article.
• Genome-wide approaches for identification of nuclear receptor target genes.
  Tavera-Mendoza LE, Mader S, White JH. Tavera-Mendoza LE, et al. Nucl Recept Signal. 2006;4:e018. doi: 10.1621/nrs.04018. Epub 2006 Jul 7. Nucl Recept Signal. 2006. PMID: 16862224 Free PMC article.
• Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects.
  Kaykhaei MA, Khodadoost M, Dashipour AR, Haidari Z, Karimkoshteh A, Sandoughi M. Kaykhaei MA, et al. Endocrine. 2019 May;64(2):378-383. doi: 10.1007/s12020-019-01881-5. Epub 2019 Mar 14. Endocrine. 2019. PMID: 30877526
• The vitamin D3 transcriptomic response in skin cells derived from the Atlantic bottlenose dolphin.
  Ellis BC, Gattoni-Celli S, Mancia A, Kindy MS. Ellis BC, et al. Dev Comp Immunol. 2009 Aug;33(8):901-12. doi: 10.1016/j.dci.2009.02.008. Epub 2009 Mar 21. Dev Comp Immunol. 2009. PMID: 19454332 Free PMC article.
• Insights into genetic and epigenetic determinants with impact on vitamin d signaling and cancer association studies: the case of thyroid cancer.
  Morand GB, da Silva SD, Hier MP, Alaoui-Jamali MA. Morand GB, et al. Front Oncol. 2014 Nov 4;4:309. doi: 10.3389/fonc.2014.00309. eCollection 2014. Front Oncol. 2014. PMID: 25414832 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information