Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis - PubMed (original) (raw)

Review

. 2004 Feb;286(2):F202-15.

doi: 10.1152/ajprenal.00157.2003.

Affiliations

• PMID: 14707006
• DOI: 10.1152/ajprenal.00157.2003

Free article

Review

Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis

Yashpal S Kanwar et al. Am J Physiol Renal Physiol. 2004 Feb.

Free article

Abstract

One of the hallmarks of mammalian nephrogenesis includes a mesenchymal-epithelial transition that is accomplished by intercalation of the ureteric bud, an epithelium-lined tubelike structure, into an undifferentiated mesenchyme, and the latter then undergoes an inductive transformation and differentiates into an epithelial phenotype. At the same time, the differentiating mesenchyme reciprocates by inducing branching morphogenesis of the ureteric bud, which forms a treelike structure with dichotomous iterations. These reciprocal inductive interactions lead to the development of a functioning nephron unit made up of a glomerulus and proximal and distal tubules. The inductive interactions and differentiation events are modulated by a number of transcription factors, protooncogenes, and growth factors and their receptors, which regulate the expression of target morphogenetic modulators including the ECM, integrin receptors, and cell adhesion molecules. These target macromolecules exhibit spatiotemporal and stage-specific developmental regulation in the metanephros. The ECM molecules expressed at the epithelial-mesenchymal interface are perhaps the most relevant and conducive to the paracrine-juxtacrine interactions in a scenario where the ligand is expressed in the mesenchyme while the receptor is located in the ureteric bud epithelium or vice versa. In addition, expression of the target ECM macromolecules is regulated by matrix metalloproteinases and their inhibitors to generate a concentration gradient at the interface to further propel epithelial-mesenchymal interactions so that nephrogenesis can proceed seamlessly. In this review, we discuss and update our current understanding of the role of the ECM and related macromolecules with respect to metanephric development.

PubMed Disclaimer

Similar articles

• Relevance of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis.
  Wallner EI, Yang Q, Peterson DR, Wada J, Kanwar YS. Wallner EI, et al. Am J Physiol. 1998 Oct;275(4):F467-77. doi: 10.1152/ajprenal.1998.275.4.F467. Am J Physiol. 1998. PMID: 9755118 Review.
• Diverse aspects of metanephric development.
  Wallner EI, Carone FA, Abrahamson DR, Kumar A, Kanwar YS. Wallner EI, et al. Microsc Res Tech. 1997 Nov 1;39(3):261-84. doi: 10.1002/(SICI)1097-0029(19971101)39:3<261::AID-JEMT6>3.0.CO;2-N. Microsc Res Tech. 1997. PMID: 9372499 Review.
• Matrix metalloproteinases in renal development.
  Haas CS, Gleason B, Lin S, Tramonti G, Kanwar YS. Haas CS, et al. Connect Tissue Res. 2004;45(2):73-85. doi: 10.1080/03008200490442644. Connect Tissue Res. 2004. PMID: 15763922 Review.
• Epithelial-mesenchymal interactions in tooth morphogenesis: the roles of extracellular matrix, growth factors, and cell surface receptors.
  Thesleff I, Partanen AM, Vainio S. Thesleff I, et al. J Craniofac Genet Dev Biol. 1991 Oct-Dec;11(4):229-37. J Craniofac Genet Dev Biol. 1991. PMID: 1725871
• Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney.
  Meyer TN, Schwesinger C, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. Meyer TN, et al. Dev Biol. 2004 Nov 1;275(1):44-67. doi: 10.1016/j.ydbio.2004.07.022. Dev Biol. 2004. PMID: 15464572

Cited by

• Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal.
  Pérez-Martínez L, Jaworski DM. Pérez-Martínez L, et al. J Neurosci. 2005 May 18;25(20):4917-29. doi: 10.1523/JNEUROSCI.5066-04.2005. J Neurosci. 2005. PMID: 15901773 Free PMC article.
• Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors.
  Batchelder CA, Lee CC, Matsell DG, Yoder MC, Tarantal AF. Batchelder CA, et al. Differentiation. 2009 Jul;78(1):45-56. doi: 10.1016/j.diff.2009.05.001. Epub 2009 Jun 4. Differentiation. 2009. PMID: 19500897 Free PMC article.
• Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.
  Langer EM, Feng Y, Zhaoyuan H, Rauscher FJ 3rd, Kroll KL, Longmore GD. Langer EM, et al. Dev Cell. 2008 Mar;14(3):424-36. doi: 10.1016/j.devcel.2008.01.005. Dev Cell. 2008. PMID: 18331720 Free PMC article.
• Thermo-sensitive hydrogels combined with decellularised matrix deliver bFGF for the functional recovery of rats after a spinal cord injury.
  Xu HL, Tian FR, Lu CT, Xu J, Fan ZL, Yang JJ, Chen PP, Huang YD, Xiao J, Zhao YZ. Xu HL, et al. Sci Rep. 2016 Dec 6;6:38332. doi: 10.1038/srep38332. Sci Rep. 2016. PMID: 27922061 Free PMC article.
• Mouse Metanephric Mesenchymal Cell-Derived Angioblasts Undergo Vasculogenesis in Three-Dimensional Culture.
  Patel M, Velagapudi C, Burns H, Doss R, Lee MJ, Mariappan MM, Wagner B, Arar M, Barnes VL, Abboud HE, Barnes JL. Patel M, et al. Am J Pathol. 2018 Mar;188(3):768-784. doi: 10.1016/j.ajpath.2017.10.022. Epub 2017 Dec 19. Am J Pathol. 2018. PMID: 29269120 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon