Control of autoimmunity by naturally arising regulatory CD4+ T cells - PubMed (original) (raw)
Review
Control of autoimmunity by naturally arising regulatory CD4+ T cells
Shohei Hori et al. Adv Immunol. 2003.
Abstract
Naturally acquired immunological self-tolerance is not entirely accounted for by clonal deletion, anergy, and ignorance. It is now well established that the T cell-repertoire of healthy individuals harbors self-reactive lymphocytes with a potential to cause autoimmune disease and these lymphocytes are under dominant control by a unique subpopulation of CD4+ T cells now called regulatory T cells. Efforts to delineate these Treg cells naturally present in normal individuals have revealed that they are enriched in the CD25+ CD4+ population. The identification of the CD25 molecule as a useful marker for naturally arising CD4+ regulatory T cells has made it possible to investigate many key aspects of their immunobiology, including their antigen specificities and the cellular/molecular pathways involved in their development and their mechanisms of action. Furthermore, reduction or dysfunction of the CD25+ CD4+ regulatory T cell population can be responsible for certain autoimmune diseases in humans.
Similar articles
- Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation.
Kuniyasu Y, Takahashi T, Itoh M, Shimizu J, Toda G, Sakaguchi S. Kuniyasu Y, et al. Int Immunol. 2000 Aug;12(8):1145-55. doi: 10.1093/intimm/12.8.1145. Int Immunol. 2000. PMID: 10917889 - Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.
Itoh M, Takahashi T, Sakaguchi N, Kuniyasu Y, Shimizu J, Otsuka F, Sakaguchi S. Itoh M, et al. J Immunol. 1999 May 1;162(9):5317-26. J Immunol. 1999. PMID: 10228007 - Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.
Coutinho A, Caramalho I, Seixas E, Demengeot J. Coutinho A, et al. Curr Top Microbiol Immunol. 2005;293:43-71. doi: 10.1007/3-540-27702-1_3. Curr Top Microbiol Immunol. 2005. PMID: 15981475 Review. - Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.
Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T. Sakaguchi S, et al. Immunol Rev. 2001 Aug;182:18-32. doi: 10.1034/j.1600-065x.2001.1820102.x. Immunol Rev. 2001. PMID: 11722621 Review. - The role of CD4+CD25+ immunoregulatory T cells in the induction of autoimmune gastritis.
Laurie KL, Van Driel IR, Gleeson PA. Laurie KL, et al. Immunol Cell Biol. 2002 Dec;80(6):567-73. doi: 10.1046/j.1440-1711.2002.01127.x. Immunol Cell Biol. 2002. PMID: 12406391
Cited by
- Treg Cell Therapeutic Strategies for Breast Cancer: Holistic to Local Aspects.
Zhang H, Felthaus O, Eigenberger A, Klein S, Prantl L. Zhang H, et al. Cells. 2024 Sep 11;13(18):1526. doi: 10.3390/cells13181526. Cells. 2024. PMID: 39329710 Free PMC article. Review. - How persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease.
Yin R, Melton S, Huseby ES, Kardar M, Chakraborty AK. Yin R, et al. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2318599121. doi: 10.1073/pnas.2318599121. Epub 2024 Mar 6. Proc Natl Acad Sci U S A. 2024. PMID: 38446856 Free PMC article. - A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy.
Chen CH, Weng TH, Huang HH, Huang LY, Huang KY, Chen PR, Yeh KY, Huang CT, Chien YT, Chuang PY, Lin YL, Tsai NM, Liu SJ, Su YC, Weng SL, Liao KW. Chen CH, et al. J Exp Clin Cancer Res. 2023 Jan 23;42(1):29. doi: 10.1186/s13046-023-02601-8. J Exp Clin Cancer Res. 2023. PMID: 36691089 Free PMC article. - Antigen Specific Regulatory T Cells in Kidney Transplantation and Other Tolerance Settings.
Hu M, Rogers NM, Li J, Zhang GY, Wang YM, Shaw K, O'Connell PJ, Alexander SI. Hu M, et al. Front Immunol. 2021 Aug 26;12:717594. doi: 10.3389/fimmu.2021.717594. eCollection 2021. Front Immunol. 2021. PMID: 34512640 Free PMC article. Review. - NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases.
Dixit N, Fanton C, Langowski JL, Kirksey Y, Kirk P, Chang T, Cetz J, Dixit V, Kim G, Kuo P, Maiti M, Tang Y, VanderVeen LA, Zhang P, Lee M, Ritz J, Kamihara Y, Ji C, Rubas W, Sweeney TD, Doberstein SK, Zalevsky J. Dixit N, et al. J Transl Autoimmun. 2021 May 6;4:100103. doi: 10.1016/j.jtauto.2021.100103. eCollection 2021. J Transl Autoimmun. 2021. PMID: 34041473 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials