The eukaryotic nucleotide excision repair pathway - PubMed (original) (raw)
Review
The eukaryotic nucleotide excision repair pathway
Renata M A Costa et al. Biochimie. 2003 Nov.
Abstract
Nucleotide excision repair (NER) is the most versatile mechanism of DNA repair, recognizing and dealing with a variety of helix-distorting lesions, such as the UV-induced photoproducts cyclobutane pyrimidine dimers (CPDs) and pyrimidine 6-4 pyrimidone photoproducts (6-4 PPs). In this review, we describe the main protein players and the different sequential steps of the eukaryotic NER mechanism in human cells, from lesion recognition to damage removal and DNA synthesis. Studies on the dynamics of protein access to the damaged site, and the kinetics of lesion removal contribute to the knowledge of how the cells respond to genetic insult. DNA lesions as well as NER factors themselves are also implicated in changes in cell metabolism, influencing cell cycle progression or arrest, apoptosis and genetic instability. These changes are related to increased mutagenesis and carcinogenesis. Finally, the recent collection of genomic data allows one to recognize the high conservation and the evolution of eukaryotic NER. The distribution of NER orthologues in different organisms, from archaea to the metazoa, displays challenging observations. Some of NER proteins are widespread in nature, probably representing ancient DNA repair proteins, which are candidates to participate in a primitive NER mechanism.
Similar articles
- Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology.
Shuck SC, Short EA, Turchi JJ. Shuck SC, et al. Cell Res. 2008 Jan;18(1):64-72. doi: 10.1038/cr.2008.2. Cell Res. 2008. PMID: 18166981 Free PMC article. Review. - DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar Efficiency.
Paul-Konietzko K, Thomale J, Arakawa H, Iliakis G. Paul-Konietzko K, et al. Photochem Photobiol. 2015 Sep-Oct;91(5):1173-80. doi: 10.1111/php.12487. Epub 2015 Aug 3. Photochem Photobiol. 2015. PMID: 26131740 - Transcription coupled repair efficiency determines the cell cycle progression and apoptosis after UV exposure in hamster cells.
Proietti De Santis L, Garcia CL, Balajee AS, Latini P, Pichierri P, Nikaido O, Stefanini M, Palitti F. Proietti De Santis L, et al. DNA Repair (Amst). 2002 Mar 28;1(3):209-23. doi: 10.1016/s1568-7864(01)00017-9. DNA Repair (Amst). 2002. PMID: 12509253 - Emerging Roles of Post-Translational Modifications in Nucleotide Excision Repair.
Borsos BN, Majoros H, Pankotai T. Borsos BN, et al. Cells. 2020 Jun 15;9(6):1466. doi: 10.3390/cells9061466. Cells. 2020. PMID: 32549338 Free PMC article. Review. - Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair.
Steurer B, Turkyilmaz Y, van Toorn M, van Leeuwen W, Escudero-Ferruz P, Marteijn JA. Steurer B, et al. Nucleic Acids Res. 2019 Apr 23;47(7):3536-3549. doi: 10.1093/nar/gkz035. Nucleic Acids Res. 2019. PMID: 30698791 Free PMC article.
Cited by
- Mapping the recognition pathway of cyclobutane pyrimidine dimer in DNA by Rad4/XPC.
Jakhar N, Prabhakant A, Krishnan M. Jakhar N, et al. Nucleic Acids Res. 2023 Oct 27;51(19):10132-10146. doi: 10.1093/nar/gkad730. Nucleic Acids Res. 2023. PMID: 37757853 Free PMC article. - The Over-Irradiation Metabolite Derivative, 24-Hydroxylumister-ol3, Reduces UV-Induced Damage in Skin.
De Silva WGM, McCarthy BY, Han J, Yang C, Holland AJA, Stern H, Dixon KM, Tang EKY, Tuckey RC, Rybchyn MS, Mason RS. De Silva WGM, et al. Metabolites. 2023 Jun 21;13(7):775. doi: 10.3390/metabo13070775. Metabolites. 2023. PMID: 37512482 Free PMC article. - Quantitative Proteomics Reveals Manganese Alleviates Heat Stress of Broiler Myocardial Cells via Regulating Nucleic Acid Metabolism.
Qin S, Wang R, Li J, Tang D, Shi Z. Qin S, et al. Biol Trace Elem Res. 2024 Mar;202(3):1187-1202. doi: 10.1007/s12011-023-03731-y. Epub 2023 Jun 27. Biol Trace Elem Res. 2024. PMID: 37369963 - Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma.
Wang G, Guo H, Ren Y, Chen W, Wang Y, Li J, Liu H, Xing J, Zhang Y, Li N. Wang G, et al. Front Pharmacol. 2023 Jun 1;14:1157433. doi: 10.3389/fphar.2023.1157433. eCollection 2023. Front Pharmacol. 2023. PMID: 37324464 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources