Bcl-w(edding) with mitochondria - PubMed (original) (raw)
Review
Bcl-w(edding) with mitochondria
Thomas Kaufmann et al. Trends Cell Biol. 2004 Jan.
Abstract
Bcl-2-family members (Bcl-2, Bax, Bcl-w and Bcl-x(L)) are crucial integrators of signals for cell survival and death; the pro- or antiapoptotic activities of these proteins are regulated by their subcellular localization. Bcl-2 directly inserts into the membranes, where it acts; however, Bax requires a stimulus-dependent translocation from an inactive cytosolic to an active membrane-inserted state. Recently, a novel mechanism is described for the survival factor Bcl-w, which is active while weakly associated with mitochondria. In apoptotic cells, a BH3-only protein neutralizes the survival activity of Bcl-w by binding to its "hydrophobic pockets", thereby releasing its C-terminal domain and allowing its insertion into the membrane. Here, we discuss the importance of this finding for a better understanding of the action mode of Bcl-w and other Bcl-2-family members.
Similar articles
- Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity.
Wilson-Annan J, O'Reilly LA, Crawford SA, Hausmann G, Beaumont JG, Parma LP, Chen L, Lackmann M, Lithgow T, Hinds MG, Day CL, Adams JM, Huang DC. Wilson-Annan J, et al. J Cell Biol. 2003 Sep 1;162(5):877-87. doi: 10.1083/jcb.200302144. J Cell Biol. 2003. PMID: 12952938 Free PMC article. - BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins.
Weber A, Paschen SA, Heger K, Wilfling F, Frankenberg T, Bauerschmitt H, Seiffert BM, Kirschnek S, Wagner H, Häcker G. Weber A, et al. J Cell Biol. 2007 May 21;177(4):625-36. doi: 10.1083/jcb.200610148. J Cell Biol. 2007. PMID: 17517961 Free PMC article. - BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.
Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. Kuwana T, et al. Mol Cell. 2005 Feb 18;17(4):525-35. doi: 10.1016/j.molcel.2005.02.003. Mol Cell. 2005. PMID: 15721256 - Structural biology of the Bcl-2 family of proteins.
Petros AM, Olejniczak ET, Fesik SW. Petros AM, et al. Biochim Biophys Acta. 2004 Mar 1;1644(2-3):83-94. doi: 10.1016/j.bbamcr.2003.08.012. Biochim Biophys Acta. 2004. PMID: 14996493 Review. - Control of mitochondrial permeability by Bcl-2 family members.
Sharpe JC, Arnoult D, Youle RJ. Sharpe JC, et al. Biochim Biophys Acta. 2004 Mar 1;1644(2-3):107-13. doi: 10.1016/j.bbamcr.2003.10.016. Biochim Biophys Acta. 2004. PMID: 14996495 Review.
Cited by
- Dynamics of Bcl-xL in water and membrane: molecular simulations.
Maity A, Yadav S, Verma CS, Ghosh Dastidar S. Maity A, et al. PLoS One. 2013 Oct 8;8(10):e76837. doi: 10.1371/journal.pone.0076837. eCollection 2013. PLoS One. 2013. PMID: 24116174 Free PMC article. - The interactions of cobalt(II) with mitochondria from rat liver.
Bragadin M, Toninello A, Mancon M, Manente S. Bragadin M, et al. J Biol Inorg Chem. 2007 Jun;12(5):631-5. doi: 10.1007/s00775-007-0222-1. Epub 2007 Mar 3. J Biol Inorg Chem. 2007. PMID: 17334796 - BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line.
Kawasaki T, Yokoi S, Tsuda H, Izumi H, Kozaki K, Aida S, Ozeki Y, Yoshizawa Y, Imoto I, Inazawa J. Kawasaki T, et al. Cancer Sci. 2007 Jul;98(7):1070-7. doi: 10.1111/j.1349-7006.2007.00491.x. Epub 2007 Apr 24. Cancer Sci. 2007. PMID: 17459056 Free PMC article. - Bcl-xL Reduces Chinese Giant Salamander Iridovirus-Induced Mitochondrial Apoptosis by Interacting with Bak and Inhibiting the p53 Pathway.
Li Y, Fan Y, Zhou Y, Jiang N, Xue M, Meng Y, Liu W, Zhang J, Lin G, Zeng L. Li Y, et al. Viruses. 2021 Nov 4;13(11):2224. doi: 10.3390/v13112224. Viruses. 2021. PMID: 34835028 Free PMC article. - Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent.
Sharma R, Sharma A, Chaudhary P, Pearce V, Vatsyayan R, Singh SV, Awasthi S, Awasthi YC. Sharma R, et al. Biochemistry. 2010 Apr 13;49(14):3191-202. doi: 10.1021/bi100104e. Biochemistry. 2010. PMID: 20205397 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials