Telomeres and the functional architecture of the nucleus - PubMed (original) (raw)

Telomeres and the functional architecture of the nucleus

E Gilson et al. Trends Cell Biol. 1993 Apr.

Abstract

The single molecule of DNA that constitutes a eukaryotic chromosome begins and ends with a stretch of repetitive DNA known as a telomere. These sequences appear to be necessary to preserve the integrity of the genetic material through the cell cycle. Telomeric DNA is organized into regions of non-nucleosomal chromatin called the telosome, which can interact with other telosomes and with the nuclear envelope. This review focuses on cytological evidence for these interactions and on recent insights into the molecular organization of the telomeric complex.

PubMed Disclaimer

Similar articles

• Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae.
  Wright JH, Zakian VA. Wright JH, et al. Nucleic Acids Res. 1995 May 11;23(9):1454-60. doi: 10.1093/nar/23.9.1454. Nucleic Acids Res. 1995. PMID: 7784196 Free PMC article.
• Cytological and functional aspects of telomere maintenance.
  Dandjinou AT, Dionne I, Gravel S, LeBel C, Parenteau J, Wellinger RJ. Dandjinou AT, et al. Histol Histopathol. 1999 Apr;14(2):517-24. doi: 10.14670/HH-14.517. Histol Histopathol. 1999. PMID: 10212814 Review.
• Specific interactions of the telomeric protein Rap1p with nucleosomal binding sites.
  Rossetti L, Cacchione S, De Menna A, Chapman L, Rhodes D, Savino M. Rossetti L, et al. J Mol Biol. 2001 Mar 9;306(5):903-13. doi: 10.1006/jmbi.2001.4458. J Mol Biol. 2001. PMID: 11237607
• Saccharomyces telomeres assume a non-nucleosomal chromatin structure.
  Wright JH, Gottschling DE, Zakian VA. Wright JH, et al. Genes Dev. 1992 Feb;6(2):197-210. doi: 10.1101/gad.6.2.197. Genes Dev. 1992. PMID: 1737616
• Nucleosome organization and chromatin dynamics in telomeres.
  Ichikawa Y, Nishimura Y, Kurumizaka H, Shimizu M. Ichikawa Y, et al. Biomol Concepts. 2015 Mar;6(1):67-75. doi: 10.1515/bmc-2014-0035. Biomol Concepts. 2015. PMID: 25720088 Review.

Cited by

• Close Ties between the Nuclear Envelope and Mammalian Telomeres: Give Me Shelter.
  Pennarun G, Picotto J, Bertrand P. Pennarun G, et al. Genes (Basel). 2023 Mar 23;14(4):775. doi: 10.3390/genes14040775. Genes (Basel). 2023. PMID: 37107534 Free PMC article. Review.
• Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells.
  Pennarun G, Picotto J, Etourneaud L, Redavid AR, Certain A, Gauthier LR, Fontanilla-Ramirez P, Busso D, Chabance-Okumura C, Thézé B, Boussin FD, Bertrand P. Pennarun G, et al. Nucleic Acids Res. 2021 Sep 27;49(17):9886-9905. doi: 10.1093/nar/gkab761. Nucleic Acids Res. 2021. PMID: 34469544 Free PMC article.
• Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells.
  Shishkin SS, Kovalev LI, Pashintseva NV, Kovaleva MA, Lisitskaya K. Shishkin SS, et al. Int J Mol Sci. 2019 Feb 10;20(3):745. doi: 10.3390/ijms20030745. Int J Mol Sci. 2019. PMID: 30744200 Free PMC article. Review.
• Mammalian telomeres and their partnership with lamins.
  Burla R, La Torre M, Saggio I. Burla R, et al. Nucleus. 2016 Apr 25;7(2):187-202. doi: 10.1080/19491034.2016.1179409. Nucleus. 2016. PMID: 27116558 Free PMC article. Review.
• Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF.
  Ottaviani A, Schluth-Bolard C, Rival-Gervier S, Boussouar A, Rondier D, Foerster AM, Morere J, Bauwens S, Gazzo S, Callet-Bauchu E, Gilson E, Magdinier F. Ottaviani A, et al. EMBO J. 2009 Aug 19;28(16):2428-36. doi: 10.1038/emboj.2009.201. Epub 2009 Jul 30. EMBO J. 2009. PMID: 19644448 Free PMC article.