Kinetochores, microtubules and the metaphase checkpoint - PubMed (original) (raw)
Kinetochores, microtubules and the metaphase checkpoint
G J Gorbsky. Trends Cell Biol. 1995 Apr.
Abstract
A decade ago, kinetochores were generally regarded as rather uninteresting structures that served only to attach mitotic chromosomes to microtubules. In the past few years, however, a number of experiments have belied this view and demonstrated that kinetochores are actively involved in moving chromosomes along the microtubules of the mitotic spindle. Now it appears that in addition to their function in motility, kinetochores act as dynamic and adaptable centres for regulating cell cycle progression through mitosis.
Similar articles
- Differential expression of a phosphoepitope at the kinetochores of moving chromosomes.
Gorbsky GJ, Ricketts WA. Gorbsky GJ, et al. J Cell Biol. 1993 Sep;122(6):1311-21. doi: 10.1083/jcb.122.6.1311. J Cell Biol. 1993. PMID: 7690762 Free PMC article. - Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores.
Sivakumar S, Gorbsky GJ. Sivakumar S, et al. Biol Open. 2017 Nov 15;6(11):1672-1679. doi: 10.1242/bio.026930. Biol Open. 2017. PMID: 28982702 Free PMC article. - CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint.
Yao X, Abrieu A, Zheng Y, Sullivan KF, Cleveland DW. Yao X, et al. Nat Cell Biol. 2000 Aug;2(8):484-91. doi: 10.1038/35019518. Nat Cell Biol. 2000. PMID: 10934468 - Merotelic kinetochores in mammalian tissue cells.
Salmon ED, Cimini D, Cameron LA, DeLuca JG. Salmon ED, et al. Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):553-68. doi: 10.1098/rstb.2004.1610. Philos Trans R Soc Lond B Biol Sci. 2005. PMID: 15897180 Free PMC article. Review. - Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle.
Rieder CL, Salmon ED. Rieder CL, et al. J Cell Biol. 1994 Feb;124(3):223-33. doi: 10.1083/jcb.124.3.223. J Cell Biol. 1994. PMID: 8294508 Free PMC article. Review.
Cited by
- Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.
Wang J, Yin Y, Hua H, Li M, Luo T, Xu L, Wang R, Liu D, Zhang Y, Jiang Y. Wang J, et al. J Cell Mol Med. 2009 Sep;13(9B):3888-97. doi: 10.1111/j.1582-4934.2009.00873.x. Epub 2009 Aug 8. J Cell Mol Med. 2009. PMID: 19674193 Free PMC article. - Breaking Bad: How Viruses Subvert the Cell Cycle.
Fan Y, Sanyal S, Bruzzone R. Fan Y, et al. Front Cell Infect Microbiol. 2018 Nov 19;8:396. doi: 10.3389/fcimb.2018.00396. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 30510918 Free PMC article. Review. - Cellular expression of human centromere protein C demonstrates a cyclic behavior with highest abundance in the G1 phase.
Knehr M, Poppe M, Schroeter D, Eickelbaum W, Finze EM, Kiesewetter UL, Enulescu M, Arand M, Paweletz N. Knehr M, et al. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10234-9. doi: 10.1073/pnas.93.19.10234. Proc Natl Acad Sci U S A. 1996. PMID: 8816782 Free PMC article. - Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.
Nicklas RB, Ward SC, Gorbsky GJ. Nicklas RB, et al. J Cell Biol. 1995 Aug;130(4):929-39. doi: 10.1083/jcb.130.4.929. J Cell Biol. 1995. PMID: 7642708 Free PMC article. - Conservation of the centromere/kinetochore protein ZW10.
Starr DA, Williams BC, Li Z, Etemad-Moghadam B, Dawe RK, Goldberg ML. Starr DA, et al. J Cell Biol. 1997 Sep 22;138(6):1289-301. doi: 10.1083/jcb.138.6.1289. J Cell Biol. 1997. PMID: 9298984 Free PMC article.
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous