Regulation of the phagocyte respiratory burst by small GTP-binding proteins - PubMed (original) (raw)
Regulation of the phagocyte respiratory burst by small GTP-binding proteins
G M Bokoch. Trends Cell Biol. 1995 Mar.
Abstract
Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
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