Hydrogen sulfide induces calcium waves in astrocytes - PubMed (original) (raw)

Comparative Study

doi: 10.1096/fj.03-1052fje. Epub 2004 Jan 20.

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Comparative Study

Hydrogen sulfide induces calcium waves in astrocytes

Yasuo Nagai et al. FASEB J. 2004 Mar.

Abstract

Hydrogen sulfide (H2S) modifies hippocampal long-term potentiation (LTP) and functions as a neuromodulator. Here, we show that H2S increases intracellular Ca2+ and induces Ca2+ waves in primary cultures of astrocytes as well as hippocampal slices. H2S increases the influx of Ca2+ and to a lesser extent causes the release from intracellular Ca2+ stores. Ca2+ waves induced by neuronal excitation as well as responses to exogenously applied H2S are potently blocked by La3+ and Gd3+, inhibitors of Ca2+ channels. These observations suggest that H2S induces Ca2+ waves that propagate to neighboring astrocytes.

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