IL-6 trans-signaling: the heat is on - PubMed (original) (raw)
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IL-6 trans-signaling: the heat is on
Stefan Rose-John et al. Immunity. 2004 Jan.
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Abstract
The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 degrees C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R.
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- Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress.
Chen Q, Wang WC, Bruce R, Li H, Schleider DM, Mulbury MJ, Bain MD, Wallace PK, Baumann H, Evans SS. Chen Q, et al. Immunity. 2004 Jan;20(1):59-70. doi: 10.1016/s1074-7613(03)00358-3. Immunity. 2004. PMID: 14738765
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