Spinocerebellar ataxia type 5: clinical and molecular genetic features of a German kindred - PubMed (original) (raw)
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Spinocerebellar ataxia type 5: clinical and molecular genetic features of a German kindred
K Bürk et al. Neurology. 2004.
Abstract
The authors report a German family with autosomal dominant cerebellar ataxia tightly linked to the spinocerebellar ataxia type 5 (SCA5) locus (multipoint lod score 5.76). The phenotype is characterized by a purely cerebellar syndrome with a downbeat nystagmus occurring prior to the development of other features. Imaging studies demonstrated cortical cerebellar atrophy. Progression is slow even in patients with a disease onset during the second decade. The age at onset varies from 15 to 50 years.
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