Contributions of sensory input, auditory search and verbal comprehension to cortical activity during speech processing - PubMed (original) (raw)
Clinical Trial
Contributions of sensory input, auditory search and verbal comprehension to cortical activity during speech processing
A L Giraud et al. Cereb Cortex. 2004 Mar.
Abstract
We studied eight normal subjects in an fMRI experiment where they listened to natural speech sentences and to matched simple or complex speech envelope noises. Neither of the noises (simple or complex) were understood initially, but after the corresponding natural speech sentences had been heard, comprehension was close to perfect for the complex but still absent for the simple speech envelope noises. This setting thus involved identical stimuli that were understood or not and permitted to identify (i) a neural substrate of speech comprehension unconfounded by stimulus acoustic properties (common to natural speech and complex noises), (ii) putative correlates of auditory search for phonetic cues in noisy stimuli (common to simple and complex noises once the matching natural speech had been heard) and (iii) the cortical regions where speech comprehension and auditory search interact. We found correlates of speech comprehension in bilateral medial (BA21) and inferior (BA38 and BA38/21) temporal regions, whereas acoustic feature processing occurred in more dorsal temporal regions. The left posterior superior temporal cortex (Wernicke's area) responded to the acoustic complexity of the stimuli but was additionally sensitive to auditory search and speech comprehension. Attention was associated with recruitment of the dorsal part of Broca's area (BA44) and interaction of auditory attention and comprehension occurred in bilateral insulae, the anterior cingulate and the right medial frontal cortex. In combination, these results delineate a neuroanatomical framework for the functional components at work during natural speech processing, i.e. when comprehension results from concurrent acoustic processing and effortful auditory search.
Similar articles
- Phonetic processing areas revealed by sinewave speech and acoustically similar non-speech.
Benson RR, Richardson M, Whalen DH, Lai S. Benson RR, et al. Neuroimage. 2006 May 15;31(1):342-53. doi: 10.1016/j.neuroimage.2005.11.029. Epub 2006 Mar 10. Neuroimage. 2006. PMID: 16530428 - Comprehension of degraded speech sounds with m-sequence modulation: an fMRI study.
Takeichi H, Koyama S, Terao A, Takeuchi F, Toyosawa Y, Murohashi H. Takeichi H, et al. Neuroimage. 2010 Feb 1;49(3):2697-706. doi: 10.1016/j.neuroimage.2009.10.063. Epub 2009 Oct 28. Neuroimage. 2010. PMID: 19878726 - Speech comprehension aided by multiple modalities: behavioural and neural interactions.
McGettigan C, Faulkner A, Altarelli I, Obleser J, Baverstock H, Scott SK. McGettigan C, et al. Neuropsychologia. 2012 Apr;50(5):762-76. doi: 10.1016/j.neuropsychologia.2012.01.010. Epub 2012 Jan 17. Neuropsychologia. 2012. PMID: 22266262 Free PMC article. - [Auditory perception and language: functional imaging of speech sensitive auditory cortex].
Samson Y, Belin P, Thivard L, Boddaert N, Crozier S, Zilbovicius M. Samson Y, et al. Rev Neurol (Paris). 2001 Sep;157(8-9 Pt 1):837-46. Rev Neurol (Paris). 2001. PMID: 11677406 Review. French. - Segmental processing in the human auditory dorsal stream.
Zaehle T, Geiser E, Alter K, Jancke L, Meyer M. Zaehle T, et al. Brain Res. 2008 Jul 18;1220:179-90. doi: 10.1016/j.brainres.2007.11.013. Epub 2007 Nov 17. Brain Res. 2008. PMID: 18096139 Review.
Cited by
- Explore the effects of overweight and smoking on spontaneous brain activity: Independent and reverse.
Gao X, Zhang M, Yang Z, Niu X, Chen J, Zhou B, Wang W, Wei Y, Cheng J, Han S, Zhang Y. Gao X, et al. Front Neurosci. 2022 Oct 12;16:944768. doi: 10.3389/fnins.2022.944768. eCollection 2022. Front Neurosci. 2022. PMID: 36312021 Free PMC article. - Transient and sustained cortical activity elicited by connected speech of varying intelligibility.
Tiitinen H, Miettinen I, Alku P, May PJ. Tiitinen H, et al. BMC Neurosci. 2012 Dec 31;13:157. doi: 10.1186/1471-2202-13-157. BMC Neurosci. 2012. PMID: 23276297 Free PMC article. - Differentiating lexical form, meaning, and structure in the neural language system.
Tyler LK, Marslen-Wilson WD, Stamatakis EA. Tyler LK, et al. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8375-80. doi: 10.1073/pnas.0408213102. Epub 2005 May 27. Proc Natl Acad Sci U S A. 2005. PMID: 15923263 Free PMC article. - Functional imaging of the auditory processing applied to speech sounds.
Patterson RD, Johnsrude IS. Patterson RD, et al. Philos Trans R Soc Lond B Biol Sci. 2008 Mar 12;363(1493):1023-35. doi: 10.1098/rstb.2007.2157. Philos Trans R Soc Lond B Biol Sci. 2008. PMID: 17827103 Free PMC article. - A Global Multiregional Proteomic Map of the Human Cerebral Cortex.
Guo Z, Shao C, Zhang Y, Qiu W, Li W, Zhu W, Yang Q, Huang Y, Pan L, Dong Y, Sun H, Xiao X, Sun W, Ma C, Zhang L. Guo Z, et al. Genomics Proteomics Bioinformatics. 2022 Aug;20(4):614-632. doi: 10.1016/j.gpb.2021.08.008. Epub 2021 Nov 8. Genomics Proteomics Bioinformatics. 2022. PMID: 34763096 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources