Small molecule-mediated density-dependent control of gene expression in prokaryotes: bioluminescence and the biosynthesis of carbapenem antibiotics - PubMed (original) (raw)
Small molecule-mediated density-dependent control of gene expression in prokaryotes: bioluminescence and the biosynthesis of carbapenem antibiotics
P Williams et al. FEMS Microbiol Lett. 1992.
Abstract
Sophisticated signal transduction systems enable prokaryotes to sense their growth environment and mount an appropriate adaptive response. Signal transduction and gene regulation through the phosphorylation of two regulatory components is now recognised as one of the major global regulatory networks in bacteria. However, not all types of sensor-regulator circuits relay information via phosphoryl transfer. The Vibrio fischeri LuxR protein which has previously been characterised as a member of the response-regulator superfamily responds to a small diffusible signal molecule N-(3-oxohexanoyl)homoserine lactone (HSL). Biosynthesis of HSL in V. fischeri is dependent on the expression of the luxI gene. Until recently, the role of HSL as an 'autoinducer' was thought to be restricted to V. fischeri and a few related marine bacteria in which it controls the onset of bioluminescence. However, we have discovered that a diverse group of terrestrial bacteria: (1) produce HSL; (2) possess genes analogous to luxI; and (3) exhibit cell density-dependent induction of bioluminesence when transformed with a recombinant plasmid carrying V. fischeri lux genes but lacking luxI. In one of these, Erwinia carotovora, HSL is shown to mediate the cell density-dependent biosynthesis of a carbapenem antibiotic.
Similar articles
- A general role for the lux autoinducer in bacterial cell signalling: control of antibiotic biosynthesis in Erwinia.
Bainton NJ, Bycroft BW, Chhabra SR, Stead P, Gledhill L, Hill PJ, Rees CE, Winson MK, Salmond GP, Stewart GS, et al. Bainton NJ, et al. Gene. 1992 Jul 1;116(1):87-91. doi: 10.1016/0378-1119(92)90633-z. Gene. 1992. PMID: 1628848 - A novel strategy for the isolation of luxI homologues: evidence for the widespread distribution of a LuxR:LuxI superfamily in enteric bacteria.
Swift S, Winson MK, Chan PF, Bainton NJ, Birdsall M, Reeves PJ, Rees CE, Chhabra SR, Hill PJ, Throup JP, et al. Swift S, et al. Mol Microbiol. 1993 Nov;10(3):511-20. doi: 10.1111/j.1365-2958.1993.tb00923.x. Mol Microbiol. 1993. PMID: 7968529 - Multiple N-acyl-L-homoserine lactone autoinducers of luminescence in the marine symbiotic bacterium Vibrio fischeri.
Kuo A, Blough NV, Dunlap PV. Kuo A, et al. J Bacteriol. 1994 Dec;176(24):7558-65. doi: 10.1128/jb.176.24.7558-7565.1994. J Bacteriol. 1994. PMID: 8002580 Free PMC article. - Quorum regulation of luminescence in Vibrio fischeri.
Dunlap PV. Dunlap PV. J Mol Microbiol Biotechnol. 1999 Aug;1(1):5-12. J Mol Microbiol Biotechnol. 1999. PMID: 10941779 Review. - The bacterial 'enigma': cracking the code of cell-cell communication.
Salmond GP, Bycroft BW, Stewart GS, Williams P. Salmond GP, et al. Mol Microbiol. 1995 May;16(4):615-24. doi: 10.1111/j.1365-2958.1995.tb02424.x. Mol Microbiol. 1995. PMID: 7476157 Review.
Cited by
- Fragmentation modes and the evolution of life cycles.
Pichugin Y, Peña J, Rainey PB, Traulsen A. Pichugin Y, et al. PLoS Comput Biol. 2017 Nov 22;13(11):e1005860. doi: 10.1371/journal.pcbi.1005860. eCollection 2017 Nov. PLoS Comput Biol. 2017. PMID: 29166656 Free PMC article. - The hierarchy quorum sensing network in Pseudomonas aeruginosa.
Lee J, Zhang L. Lee J, et al. Protein Cell. 2015 Jan;6(1):26-41. doi: 10.1007/s13238-014-0100-x. Epub 2014 Sep 25. Protein Cell. 2015. PMID: 25249263 Free PMC article. Review. - Culture history and population heterogeneity as determinants of bacterial adaptation: the adaptomics of a single environmental transition.
Ryall B, Eydallin G, Ferenci T. Ryall B, et al. Microbiol Mol Biol Rev. 2012 Sep;76(3):597-625. doi: 10.1128/MMBR.05028-11. Microbiol Mol Biol Rev. 2012. PMID: 22933562 Free PMC article. Review. - LuxS-based quorum sensing does not affect the ability of Salmonella enterica serovar Typhimurium to express the SPI-1 type 3 secretion system, induce membrane ruffles, or invade epithelial cells.
Perrett CA, Karavolos MH, Humphrey S, Mastroeni P, Martinez-Argudo I, Spencer H, Bulmer D, Winzer K, McGhie E, Koronakis V, Williams P, Khan CM, Jepson MA. Perrett CA, et al. J Bacteriol. 2009 Dec;191(23):7253-9. doi: 10.1128/JB.00727-09. Epub 2009 Sep 25. J Bacteriol. 2009. PMID: 19783624 Free PMC article. - Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses.
Karavolos MH, Spencer H, Bulmer DM, Thompson A, Winzer K, Williams P, Hinton JC, Khan CM. Karavolos MH, et al. BMC Genomics. 2008 Oct 6;9:458. doi: 10.1186/1471-2164-9-458. BMC Genomics. 2008. PMID: 18837991 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources