Transformation-mediated exchange of virulence determinants by co-cultivation of pathogenic Neisseriae - PubMed (original) (raw)
Transformation-mediated exchange of virulence determinants by co-cultivation of pathogenic Neisseriae
M Frosch et al. FEMS Microbiol Lett. 1992.
Abstract
The horizontal flow of genetic material between microbes utilizes three principal routes: conjugation, transduction and transformation. While the significance in nature of the first two pathways is generally accepted, the in vivo role of transformation remains uncertain, despite the early observations by Griffith in 1928 on the transformation of streptococci from an avirulent to a virulent state [1]. Recently, circumstantial evidence was collected suggesting a role for transformation-mediated horizontal exchange in the modulation of virulence determinants of pathogenic Neisseriae and the variation of surface structures. In order to further assess the significance of transformation-mediated exchange we performed simple co-cultivation experiments of different Neisseria strains. We observed an efficient intra- and interspecies transfer of essential virulence determinants; the process was sensitive to the presence of DNaseI in the culture and was blocked in transformation-deficient recipients.
Similar articles
- Genome sequencing reveals widespread virulence gene exchange among human Neisseria species.
Marri PR, Paniscus M, Weyand NJ, Rendón MA, Calton CM, Hernández DR, Higashi DL, Sodergren E, Weinstock GM, Rounsley SD, So M. Marri PR, et al. PLoS One. 2010 Jul 28;5(7):e11835. doi: 10.1371/journal.pone.0011835. PLoS One. 2010. PMID: 20676376 Free PMC article. - Where does Neisseria acquire foreign DNA from: an examination of the source of genomic and pathogenic islands and the evolution of the Neisseria genus.
Putonti C, Nowicki B, Shaffer M, Fofanov Y, Nowicki S. Putonti C, et al. BMC Evol Biol. 2013 Sep 4;13:184. doi: 10.1186/1471-2148-13-184. BMC Evol Biol. 2013. PMID: 24007216 Free PMC article. - The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'.
Snyder LA, Saunders NJ. Snyder LA, et al. BMC Genomics. 2006 May 30;7:128. doi: 10.1186/1471-2164-7-128. BMC Genomics. 2006. PMID: 16734888 Free PMC article. - Population genomics: diversity and virulence in the Neisseria.
Maiden MC. Maiden MC. Curr Opin Microbiol. 2008 Oct;11(5):467-71. doi: 10.1016/j.mib.2008.09.002. Epub 2008 Oct 14. Curr Opin Microbiol. 2008. PMID: 18822386 Free PMC article. Review. - [Pathogenic neisseriae--model of bacterial virulence and genetic flexibility].
Meyer TF. Meyer TF. Immun Infekt. 1989 Aug;17(4):113-23. Immun Infekt. 1989. PMID: 2570747 Review. German.
Cited by
- Differential distribution of novel restriction-modification systems in clonal lineages of Neisseria meningitidis.
Claus H, Friedrich A, Frosch M, Vogel U. Claus H, et al. J Bacteriol. 2000 Mar;182(5):1296-303. doi: 10.1128/JB.182.5.1296-1303.2000. J Bacteriol. 2000. PMID: 10671450 Free PMC article. - Bacterial ghosts as adjuvants: mechanisms and potential.
Hajam IA, Dar PA, Won G, Lee JH. Hajam IA, et al. Vet Res. 2017 Jun 24;48(1):37. doi: 10.1186/s13567-017-0442-5. Vet Res. 2017. PMID: 28645300 Free PMC article. Review. - Transcriptome analysis of Neisseria meningitidis during infection.
Dietrich G, Kurz S, Hübner C, Aepinus C, Theiss S, Guckenberger M, Panzner U, Weber J, Frosch M. Dietrich G, et al. J Bacteriol. 2003 Jan;185(1):155-64. doi: 10.1128/JB.185.1.155-164.2003. J Bacteriol. 2003. PMID: 12486052 Free PMC article. - Hydrochloric acid-treated Bacillus subtilis ghosts induce IL-1 beta, IL-6, and TNF-alpha in murine macrophage.
Kim YM, Lee KS, Kim WM, Kim M, Park HO, Choi CW, Han JS, Park SY, Lee KS. Kim YM, et al. Mol Cell Toxicol. 2022;18(2):267-276. doi: 10.1007/s13273-022-00221-5. Epub 2022 Jan 18. Mol Cell Toxicol. 2022. PMID: 35069752 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources