Interactions between oligodendrocytes and microglia. A major role for complement and tumour necrosis factor in oligodendrocyte adherence and killing - PubMed (original) (raw)
. 1992 Dec:115 ( Pt 6):1611-31.
Affiliations
- PMID: 1486453
Interactions between oligodendrocytes and microglia. A major role for complement and tumour necrosis factor in oligodendrocyte adherence and killing
J P Zajicek et al. Brain. 1992 Dec.
Abstract
Interactions between rat microglia and oligodendrocytes were examined in vitro in order to characterize the stages of adherence, phagocytosis and cytotoxicity against oligodendrocytes by microglia. Under resting conditions, microglia showed minimal contact with oligodendrocytes and exhibited surface staining of myelin basic protein and myelin debris only; they were not cytotoxic for oligodendrocytes and did not produce tumour necrosis factor (TNF). On activation with either gamma-interferon or lipopolysaccharide and interferon, these cells increased surface binding for myelin basic protein, showed greater contact with living oligodendrocytes and produced TNF in both secreted and cell surface bound forms. Secreted TNF was capable of killing oligodendrocytes but the cell surface bound form did this more efficiently. In the presence of complement, activated microglia showed significant phagocytosis of myelin basic protein which was not obvious in the unactivated cells. These results suggest that activated microglia in the presence of complement are sufficient to kill and phagocytose the oligodendrocyte-myelin complex in vitro.
Similar articles
- Oligodendrocyte lysis by CD4+ T cells independent of tumor necrosis factor.
Antel JP, Williams K, Blain M, McRea E, McLaurin J. Antel JP, et al. Ann Neurol. 1994 Mar;35(3):341-8. doi: 10.1002/ana.410350315. Ann Neurol. 1994. PMID: 7510099 - Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats.
Mann SA, Versmold B, Marx R, Stahlhofen S, Dietzel ID, Heumann R, Berger R. Mann SA, et al. J Neuroinflammation. 2008 Sep 22;5:39. doi: 10.1186/1742-2094-5-39. J Neuroinflammation. 2008. PMID: 18808689 Free PMC article. - In vitro evidence for a dual role of tumor necrosis factor-alpha in human immunodeficiency virus type 1 encephalopathy.
Wilt SG, Milward E, Zhou JM, Nagasato K, Patton H, Rusten R, Griffin DE, O'Connor M, Dubois-Dalcq M. Wilt SG, et al. Ann Neurol. 1995 Mar;37(3):381-94. doi: 10.1002/ana.410370315. Ann Neurol. 1995. PMID: 7695238 - Proliferation of differentiated glial cells in the brain stem.
Barradas PC, Cavalcante LA. Barradas PC, et al. Braz J Med Biol Res. 1998 Feb;31(2):257-70. doi: 10.1590/s0100-879x1998000200009. Braz J Med Biol Res. 1998. PMID: 9686148 Review. - Immune-mediated oligodendrocyte injury.
Compston DA, Scolding NJ. Compston DA, et al. Ann N Y Acad Sci. 1991;633:196-204. doi: 10.1111/j.1749-6632.1991.tb15610.x. Ann N Y Acad Sci. 1991. PMID: 1789547 Review. No abstract available.
Cited by
- Mechanism of myelin breakdown in experimental demyelination: a putative role for calpain.
Schaecher KE, Shields DC, Banik NL. Schaecher KE, et al. Neurochem Res. 2001 Jun;26(6):731-7. doi: 10.1023/a:1010903823668. Neurochem Res. 2001. PMID: 11519732 Review. - Analysis of shared underlying mechanism in neurodegenerative disease.
Butler R, Bradford D, Rodgers KE. Butler R, et al. Front Aging Neurosci. 2022 Nov 29;14:1006089. doi: 10.3389/fnagi.2022.1006089. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36523957 Free PMC article. Review. - Intrauterine inflammation induces sex-specific effects on neuroinflammation, white matter, and behavior.
Makinson R, Lloyd K, Rayasam A, McKee S, Brown A, Barila G, Grissom N, George R, Marini M, Fabry Z, Elovitz M, Reyes TM. Makinson R, et al. Brain Behav Immun. 2017 Nov;66:277-288. doi: 10.1016/j.bbi.2017.07.016. Epub 2017 Jul 21. Brain Behav Immun. 2017. PMID: 28739513 Free PMC article. - A microglial hypothesis of globoid cell leukodystrophy pathology.
Nicaise AM, Bongarzone ER, Crocker SJ. Nicaise AM, et al. J Neurosci Res. 2016 Nov;94(11):1049-61. doi: 10.1002/jnr.23773. J Neurosci Res. 2016. PMID: 27638591 Free PMC article. Review. - Polarization of macrophages and microglia in inflammatory demyelination.
Cao L, He C. Cao L, et al. Neurosci Bull. 2013 Apr;29(2):189-98. doi: 10.1007/s12264-013-1324-0. Epub 2013 Apr 5. Neurosci Bull. 2013. PMID: 23558588 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources