Defect in biosynthesis of the linkage unit between peptidoglycan and teichoic acid in a bacteriophage-resistant mutant of Staphylococcus aureus - PubMed (original) (raw)
Defect in biosynthesis of the linkage unit between peptidoglycan and teichoic acid in a bacteriophage-resistant mutant of Staphylococcus aureus
R Bracha et al. J Bacteriol. 1978 May.
Abstract
The biosynthesis of the linkage region between peptidoglycan and the ribitol teichoic acid was investigated in the bacteriophage-resistant, teichoic acid-less mutant Staphylococcus aureus 52A5 (Chatterjee et al., J. Bacteriol. 100:846--853, 1969). Membrane preparations of this strain were found to be incapable of forming the first intermediate of the biosynthetic pathway, namely, the transfer of N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the acceptor molecule, which presumbably is undecaprenol phosphate (R. Bracha and L. Glaser, Biochem. Biophys. Res. Commun. 72:1091--1098, 1976). The addition of heat-inactivated membrane preparations of S. aureus 52A2 (which normally has ribitol teichoic acid) that had been preincubated with UDP-GlcNAc to membranes of strain 52A5 enabled the synthesis of teichoic acid. These data suggest that the mutational defect in the teichoic acid-less organism is in the synthesis of the first compound of the linkage unit, and this is apparently the reason for its absence in the cell walls.
Similar articles
- Structure of linkage region between ribitol teichoic acid and peptidoglycan in cell walls of Staphylococcus aureus H.
Kojima N, Araki Y, Ito E. Kojima N, et al. J Biol Chem. 1983 Aug 10;258(15):9043-5. J Biol Chem. 1983. PMID: 6874676 - Structure and functions of linkage unit intermediates in the biosynthesis of ribitol teichoic acids in Staphylococcus aureus H and Bacillus subtilis W23.
Yokoyama K, Miyashita T, Araki Y, Ito E. Yokoyama K, et al. Eur J Biochem. 1986 Dec 1;161(2):479-89. doi: 10.1111/j.1432-1033.1986.tb10469.x. Eur J Biochem. 1986. PMID: 3096735 - Studies on the linkage between teichoic acid and peptidoglycan in a bacteriophage-resistant mutant of Staphylococcus aureus H.
Heckels JE, Archibald AR, Baddiley J. Heckels JE, et al. Biochem J. 1975 Sep;149(3):637-47. doi: 10.1042/bj1490637. Biochem J. 1975. PMID: 128354 Free PMC article. - Pathways and roles of wall teichoic acid glycosylation in Staphylococcus aureus.
Winstel V, Xia G, Peschel A. Winstel V, et al. Int J Med Microbiol. 2014 May;304(3-4):215-21. doi: 10.1016/j.ijmm.2013.10.009. Epub 2013 Nov 1. Int J Med Microbiol. 2014. PMID: 24365646 Review. - Occurrence and function of membrane teichoic acids.
Lambert PA, Hancock IC, Baddiley J. Lambert PA, et al. Biochim Biophys Acta. 1977 May 31;472(1):1-12. doi: 10.1016/0304-4157(77)90012-0. Biochim Biophys Acta. 1977. PMID: 406922 Review.
Cited by
- Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus.
Schaefer K, Owens TW, Kahne D, Walker S. Schaefer K, et al. J Am Chem Soc. 2018 Feb 21;140(7):2442-2445. doi: 10.1021/jacs.7b13551. Epub 2018 Feb 9. J Am Chem Soc. 2018. PMID: 29402087 Free PMC article. - Wall teichoic acid function, biosynthesis, and inhibition.
Swoboda JG, Campbell J, Meredith TC, Walker S. Swoboda JG, et al. Chembiochem. 2010 Jan 4;11(1):35-45. doi: 10.1002/cbic.200900557. Chembiochem. 2010. PMID: 19899094 Free PMC article. Review. No abstract available. - Fractionation studies of the enzyme complex involved in teichoic acid synthesis.
Leaver J, Hancock IC, Baddiley J. Leaver J, et al. J Bacteriol. 1981 Jun;146(3):847-52. doi: 10.1128/jb.146.3.847-852.1981. J Bacteriol. 1981. PMID: 7240085 Free PMC article. - Immunoglobulin E antibodies against Staphylococcus aureus cell walls in the sera of patients with hyperimmunoglobulinemia E and recurrent staphylococcal infection.
Schopfer K, Douglas SD, Wilkinson BJ. Schopfer K, et al. Infect Immun. 1980 Feb;27(2):563-8. doi: 10.1128/iai.27.2.563-568.1980. Infect Immun. 1980. PMID: 6991418 Free PMC article. - Wall teichoic acids of gram-positive bacteria.
Brown S, Santa Maria JP Jr, Walker S. Brown S, et al. Annu Rev Microbiol. 2013;67:313-36. doi: 10.1146/annurev-micro-092412-155620. Annu Rev Microbiol. 2013. PMID: 24024634 Free PMC article. Review.
References
- J Bacteriol. 1969 Nov;100(2):846-53 - PubMed
- J Bacteriol. 1969 May;98(2):519-27 - PubMed
- Biochem Biophys Res Commun. 1972 Mar 10;46(5):1909-17 - PubMed
- Biochim Biophys Acta. 1973 Dec 28;300(4):467-85 - PubMed
- Essays Biochem. 1972;8:35-77 - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources