Genetic determinants of arterial calcification associated with atherosclerosis - PubMed (original) (raw)
Review
. 2004 Feb;79(2):197-210.
doi: 10.4065/79.2.197.
Affiliations
- PMID: 14959915
- DOI: 10.4065/79.2.197
Review
Genetic determinants of arterial calcification associated with atherosclerosis
Terence M Doherty et al. Mayo Clin Proc. 2004 Feb.
Abstract
Increasing research interest has focused on arterial calcification in the setting of atherosclerosis. Many features of atherosclerosis-related calcification provide useful clinical information. For example, calcium mineral deposits frequently form in atherosclerotic plaque, and intimal arterial calcification can be used as a surrogate marker for atherosclerosis; also, calcium deposits are readily and noninvasively quantified, which is useful because greater amounts of coronary calcification predict a higher risk of myocardial infarction and death. Several mechanisms leading to calcification associated with atherosclerosis have been proposed; however, no direct testing of proposed mechanisms has yet been reported. Studies in genetically altered animals and in humans have shed light on potential genetic determinants, which in turn could form the basis for a more comprehensive understanding of the factors affecting calcification within plaque and the associated pathobiologic implications. We review proposed molecular and cellular mechanisms of atherosclerosis-associated arterial calcification, summarize genetic influences, and suggest areas in which further investigation is needed. Understanding the molecular and genetic determinants of specific structural plaque components such as calcification can provide a solid foundation for the development of novel therapeutic approaches to favorably alter plaque structure and minimize vulnerability to arterial rupture.
Similar articles
- Molecular, endocrine, and genetic mechanisms of arterial calcification.
Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, Fishbein MC, Detrano RC, Shah PK, Rajavashisth TB. Doherty TM, et al. Endocr Rev. 2004 Aug;25(4):629-72. doi: 10.1210/er.2003-0015. Endocr Rev. 2004. PMID: 15294885 Review. - Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease.
Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA. Liu PY, et al. J Clin Endocrinol Metab. 2005 Feb;90(2):1041-6. doi: 10.1210/jc.2004-1211. Epub 2004 Nov 9. J Clin Endocrinol Metab. 2005. PMID: 15536156 - Molecular determinants of arterial calcification.
Schinke T, McKee MD, Kiviranta R, Karsenty G. Schinke T, et al. Ann Med. 1998 Dec;30(6):538-41. Ann Med. 1998. PMID: 9920355 - Media calcification and intima calcification are distinct entities in chronic kidney disease.
Amann K. Amann K. Clin J Am Soc Nephrol. 2008 Nov;3(6):1599-605. doi: 10.2215/CJN.02120508. Epub 2008 Sep 24. Clin J Am Soc Nephrol. 2008. PMID: 18815240 Review. - [Arterial media calcification in patients with type 2 diabetes mellitus].
Belovici MI, Pandele GI. Belovici MI, et al. Rev Med Chir Soc Med Nat Iasi. 2008 Jan-Mar;112(1):21-34. Rev Med Chir Soc Med Nat Iasi. 2008. PMID: 18677900 Review. Romanian.
Cited by
- Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease.
Waldron C, Zafar MA, Ziganshin BA, Weininger G, Grewal N, Elefteriades JA. Waldron C, et al. Int J Mol Sci. 2023 Oct 27;24(21):15640. doi: 10.3390/ijms242115640. Int J Mol Sci. 2023. PMID: 37958625 Free PMC article. Review. - Histology and Immunohistochemistry of Radial Arteries Are Suggestive of an Interaction between Calcification and Early Atherosclerotic Lesions in Chronic Kidney Disease.
Lysitska A, Galanis N, Skandalos I, Nikolaidou C, Briza S, Fylaktou A, Lioulios G, Mitsoglou Z, Papadopoulou D, Antoniadis N, Papagianni A, Stangou M. Lysitska A, et al. Medicina (Kaunas). 2021 Oct 24;57(11):1156. doi: 10.3390/medicina57111156. Medicina (Kaunas). 2021. PMID: 34833374 Free PMC article. - Epidemiological Research Advances in Vascular Calcification in Diabetes.
Yao H, Sun Z, Zang G, Zhang L, Hou L, Shao C, Wang Z. Yao H, et al. J Diabetes Res. 2021 Oct 1;2021:4461311. doi: 10.1155/2021/4461311. eCollection 2021. J Diabetes Res. 2021. PMID: 34631895 Free PMC article. Review. - Genetic variants in cardiac calcification in Northern Sweden.
Hellman U, Mörner S, Henein M. Hellman U, et al. Medicine (Baltimore). 2019 Apr;98(15):e15065. doi: 10.1097/MD.0000000000015065. Medicine (Baltimore). 2019. PMID: 30985656 Free PMC article. - Genetics of Subclinical Coronary Atherosclerosis.
Bielak LF, Peyser PA. Bielak LF, et al. Curr Genet Med Rep. 2018 Sep;6(3):116-123. doi: 10.1007/s40142-018-0145-x. Epub 2018 Jul 13. Curr Genet Med Rep. 2018. PMID: 30854262 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- 7R01-HL43277-02/HL/NHLBI NIH HHS/United States
- HL51736/HL/NHLBI NIH HHS/United States
- HL51980/HL/NHLBI NIH HHS/United States
- HL58555/HL/NHLBI NIH HHS/United States
- K24RR017593-01/RR/NCRR NIH HHS/United States
LinkOut - more resources
Full Text Sources