Low dose preoperative radiotherapy for carcinoma of the oesophagus: results of a randomized clinical trial - PubMed (original) (raw)
Clinical Trial
Low dose preoperative radiotherapy for carcinoma of the oesophagus: results of a randomized clinical trial
S J Arnott et al. Radiother Oncol. 1992 Jun.
Abstract
One-hundred-and-seventy-six patients with potentially operable squamous cell carcinoma or adenocarcinoma of the middle or lower thirds of the oesophagus were randomly assigned to preoperative radiotherapy or surgery alone. Patients assigned to the radiotherapy arm received 20 Gy in 10 treatments over 2 weeks, using parallel opposed 4 MV beams. The preoperative radiotherapy was not associated with any significant acute morbidity or any increase in operative complications. The median survival of the overall group of 176 patients was 8 months, and the 5-year survival was 13%. There was no significant difference in the survival of the 90 patients who received preoperative radiotherapy and the 86 who were managed by surgery alone. Proportional hazards analysis identified lymph node involvement, high tumour grade and male sex as significant adverse prognostic features, but the treatment option assigned had no prognostic significance. It was concluded that low dose preoperative radiotherapy offered no advantage over surgery alone.
Similar articles
- Mature survival results with preoperative cisplatin, protracted infusion 5-fluorouracil, and 44-Gy radiotherapy for esophageal cancer.
Kleinberg L, Knisely JP, Heitmiller R, Zahurak M, Salem R, Burtness B, Heath EI, Forastiere AA. Kleinberg L, et al. Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):328-34. doi: 10.1016/s0360-3016(02)04598-4. Int J Radiat Oncol Biol Phys. 2003. PMID: 12738305 Clinical Trial. - Patterns of failure following combined modality therapy for esophageal cancer, 1984-1990.
Kavanagh B, Anscher M, Leopold K, Deutsch M, Gaydica E, Dodge R, Allen K, Allen D, Staub W, Montana G, et al. Kavanagh B, et al. Int J Radiat Oncol Biol Phys. 1992;24(4):633-42. doi: 10.1016/0360-3016(92)90708-p. Int J Radiat Oncol Biol Phys. 1992. PMID: 1429085 - Intensive chemoradiation followed by esophagectomy for squamous cell and adenocarcinoma of the esophagus.
Forastiere AA, Heitmiller RF, Lee DJ, Zahurak M, Abrams R, Kleinberg L, Watkins S, Yeo CJ, Lillemoe KD, Sitzmann JV, Sharfman W. Forastiere AA, et al. Cancer J Sci Am. 1997 May-Jun;3(3):144-52. Cancer J Sci Am. 1997. PMID: 9161779 - Chemotherapy and radiation therapy before transhiatal esophagectomy for esophageal carcinoma.
Orringer MB, Forastiere AA, Perez-Tamayo C, Urba S, Takasugi BJ, Bromberg J. Orringer MB, et al. Ann Thorac Surg. 1990 Mar;49(3):348-54; discussion 354-5. doi: 10.1016/0003-4975(90)90237-z. Ann Thorac Surg. 1990. PMID: 2106845 Review. - [Radiochemotherapy for oesophageal cancer: a locoregional failure history].
Créhange G, Maingon P, Bosset JF. Créhange G, et al. Cancer Radiother. 2008 Nov;12(6-7):640-8. doi: 10.1016/j.canrad.2008.09.007. Epub 2008 Oct 8. Cancer Radiother. 2008. PMID: 18845466 Review. French.
Cited by
- Treatment results of preoperative concurrent chemoradiotherapy followed by surgery for stage III or IV esophageal squamous cell carcinoma.
Yamashita H, Nakagawa K, Tago M, Nakamura N, Shiraishi K, Mafune K, Kaminishi M, Ohtomo K. Yamashita H, et al. Radiat Med. 2006 Jan;24(1):65-71. doi: 10.1007/BF02489991. Radiat Med. 2006. PMID: 16715664 - Diagnosis and treatment of esophageal neoplasms.
Kato H. Kato H. Jpn J Cancer Res. 1995 Nov;86(11):993-1009. doi: 10.1111/j.1349-7006.1995.tb03012.x. Jpn J Cancer Res. 1995. PMID: 8567405 Free PMC article. Review. - Treatment outcomes of resected esophageal cancer.
Hofstetter W, Swisher SG, Correa AM, Hess K, Putnam JB Jr, Ajani JA, Dolormente M, Francisco R, Komaki RR, Lara A, Martin F, Rice DC, Sarabia AJ, Smythe WR, Vaporciyan AA, Walsh GL, Roth JA. Hofstetter W, et al. Ann Surg. 2002 Sep;236(3):376-84; discussion 384-5. doi: 10.1097/00000658-200209000-00014. Ann Surg. 2002. PMID: 12192324 Free PMC article. - Prognostic and Predictive Factors for the Curative Treatment of Esophageal and Gastric Cancer in Randomized Controlled Trials: A Systematic Review and Meta-Analysis.
van den Ende T, Ter Veer E, Mali RMA, van Berge Henegouwen MI, Hulshof MCCM, van Oijen MGH, van Laarhoven HWM. van den Ende T, et al. Cancers (Basel). 2019 Apr 12;11(4):530. doi: 10.3390/cancers11040530. Cancers (Basel). 2019. PMID: 31013858 Free PMC article. - Construction and Verification of a Hypoxia-Stemness-Based Gene Signature for Risk Stratification in Esophageal Cancer.
Tang K, Cheng Y, Li Q. Tang K, et al. Med Sci Monit. 2021 Oct 30;27:e934359. doi: 10.12659/MSM.934359. Med Sci Monit. 2021. PMID: 34716287 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical