Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk - PubMed (original) (raw)
Clinical Trial
. 2004 Feb 18;43(4):678-83.
doi: 10.1016/j.jacc.2003.07.050.
Affiliations
- PMID: 14975482
- DOI: 10.1016/j.jacc.2003.07.050
Free article
Clinical Trial
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Hans K Meier-Ewert et al. J Am Coll Cardiol. 2004.
Free article
Abstract
Objectives: We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels.
Background: Concentrations of high-sensitivity CRP are predictive of future cardiovascular morbidity. In epidemiologic studies, short sleep duration and sleep complaints have also been associated with increased cardiovascular morbidity. Two studies were undertaken to examine the effect of acute total and short-term partial sleep deprivation on concentrations of high-sensitivity CRP in healthy human subjects.
Methods: In Experiment 1, 10 healthy adult subjects stayed awake for 88 continuous hours. Samples of high-sensitivity CRP were collected every 90 min for 5 consecutive days, encompassing the vigil. In Experiment 2, 10 subjects were randomly assigned to either 8.2 h (control) or 4.2 h (partial sleep deprivation) of nighttime sleep for 10 consecutive days. Hourly samples of high-sensitivity CRP were taken during a baseline night and on day 10 of the study protocol.
Results: The CRP concentrations increased during both total and partial sleep deprivation conditions, but remained stable in the control condition. Systolic blood pressure increased across deprivation in Experiment 1, and heart rate increased in Experiment 2.
Conclusions: Both acute total and short-term partial sleep deprivation resulted in elevated high-sensitivity CRP concentrations, a stable marker of inflammation that has been shown to be predictive of cardiovascular morbidity. We propose that sleep loss may be one of the ways that inflammatory processes are activated and contribute to the association of sleep complaints, short sleep duration, and cardiovascular morbidity observed in epidemiologic surveys.
Comment in
- Does nondipping blood pressure profile contribute to vascular inflammation during sleep deprivation?
Desideri G, Croce G, Ferri C. Desideri G, et al. J Am Coll Cardiol. 2004 Oct 6;44(7):1529-30; author reply 1530-1. doi: 10.1016/j.jacc.2004.07.008. J Am Coll Cardiol. 2004. PMID: 15464344 No abstract available.
Similar articles
- [Inflammation and C-reactive protein in cardiovascular disease].
Munk PS, Larsen AI. Munk PS, et al. Tidsskr Nor Laegeforen. 2009 Jun 11;129(12):1221-4. doi: 10.4045/tidsskr.08.0011. Tidsskr Nor Laegeforen. 2009. PMID: 19521445 Review. Norwegian. - Association between coffee consumption and markers of inflammation and cardiovascular function during mental stress.
Hamer M, Williams ED, Vuononvirta R, Gibson EL, Steptoe A. Hamer M, et al. J Hypertens. 2006 Nov;24(11):2191-7. doi: 10.1097/01.hjh.0000249696.19360.be. J Hypertens. 2006. PMID: 17053540 Clinical Trial. - Waist circumference adds to the variance in plasma C-reactive protein levels in elderly patients with metabolic syndrome.
Dupuy AM, Jaussent I, Lacroux A, Durant R, Cristol JP, Delcourt C. Dupuy AM, et al. Gerontology. 2007;53(6):329-39. doi: 10.1159/000103555. Epub 2007 Jun 5. Gerontology. 2007. PMID: 17551260 - Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome.
Santos AC, Lopes C, Guimarães JT, Barros H. Santos AC, et al. Int J Obes (Lond). 2005 Dec;29(12):1452-6. doi: 10.1038/sj.ijo.0803035. Int J Obes (Lond). 2005. PMID: 16077717 - C-reactive protein: a new risk assessment tool for cardiovascular disease.
Clearfield MB. Clearfield MB. J Am Osteopath Assoc. 2005 Sep;105(9):409-16. J Am Osteopath Assoc. 2005. PMID: 16239491 Review.
Cited by
- Association of meeting the 24-h movement guidelines with high blood pressure in adolescents: a cross-sectional study.
Christofaro DGD, Ferrari G, Cucato GG, Mota J, Silva DR, Vanderlei LCM, Tebar WR, Brazo-Sayavera J. Christofaro DGD, et al. Sci Rep. 2024 Jul 24;14(1):17060. doi: 10.1038/s41598-024-68063-w. Sci Rep. 2024. PMID: 39048634 Free PMC article. - Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance.
Wright KP Jr, Drake AL, Frey DJ, Fleshner M, Desouza CA, Gronfier C, Czeisler CA. Wright KP Jr, et al. Brain Behav Immun. 2015 Jul;47:24-34. doi: 10.1016/j.bbi.2015.01.004. Epub 2015 Jan 29. Brain Behav Immun. 2015. PMID: 25640603 Free PMC article. - Differential effects of an experimental model of prolonged sleep disturbance on inflammation in healthy females and males.
Besedovsky L, Dang R, Engert LC, Goldstein MR, Devine JK, Bertisch SM, Mullington JM, Simpson N, Haack M. Besedovsky L, et al. PNAS Nexus. 2022 Mar;1(1):pgac004. doi: 10.1093/pnasnexus/pgac004. Epub 2022 Mar 10. PNAS Nexus. 2022. PMID: 36380854 Free PMC article. - Lack of association between objectively assessed sleep disorders and inflammatory markers among kidney transplant recipients.
Fornadi K, Lindner A, Czira ME, Szentkiralyi A, Lazar AS, Zoller R, Turanyi CZ, Veber O, Novak M, Mucsi I, Molnar MZ. Fornadi K, et al. Int Urol Nephrol. 2012 Apr;44(2):607-17. doi: 10.1007/s11255-011-0095-7. Epub 2011 Dec 6. Int Urol Nephrol. 2012. PMID: 22143277 - Sleep-immune system interaction: advantages and challenges of human sleep loss model.
Manzar MD, Hussain ME. Manzar MD, et al. Front Neurol. 2012 Jan 16;3:2. doi: 10.3389/fneur.2012.00002. eCollection 2012. Front Neurol. 2012. PMID: 22291681 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous