Avian influenza A (H5N1) in 10 patients in Vietnam - PubMed (original) (raw)
. 2004 Mar 18;350(12):1179-88.
doi: 10.1056/NEJMoa040419. Epub 2004 Feb 25.
Thanh Liem Nguyen, Thi Dung Nguyen, Thi San Luong, Phuong Mai Pham, van Vinh Chau Nguyen, Thi Suu Pham, Cong Dong Vo, Thi Quynh Mai Le, Thi Thi Ngo, Bach Khoa Dao, Phuc Phat Le, Thanh Truong Nguyen, Thuy Long Hoang, Viet Tung Cao, Truong Giang Le, Dac Tho Nguyen, Hong Nga Le, Kim Tien Nguyen, Hoang San Le, Van Tuan Le, Dolecek Christiane, Tan Thanh Tran, de Jong Menno, Constance Schultsz, Peter Cheng, Wilina Lim, Peter Horby, Jeremy Farrar; World Health Organization International Avian Influenza Investigative Team
Affiliations
- PMID: 14985470
- DOI: 10.1056/NEJMoa040419
Free article
Avian influenza A (H5N1) in 10 patients in Vietnam
Tinh Hien Tran et al. N Engl J Med. 2004.
Free article
Abstract
Background: Recent outbreaks of avian influenza A (H5N1) in poultry throughout Asia have had major economic and health repercussions. Human infections with this virus were identified in Vietnam in January 2004.
Methods: We report the clinical features and preliminary epidemiologic findings among 10 patients with confirmed cases of avian influenza A (H5N1) who presented to hospitals in Ho Chi Minh City and Hanoi, Vietnam, in December 2003 and January 2004.
Results: In all 10 cases, the diagnosis of influenza A (H5N1) was confirmed by means of viral culture or reverse transcriptase-polymerase chain reaction with primers specific for H5 and N1. None of the 10 patients (mean age, 13.7 years) had preexisting medical conditions. Nine of them had a clear history of direct contact with poultry (median time before onset of illness, three days). All patients presented with fever (temperature, 38.5 to 40.0 degrees C), respiratory symptoms, and clinically significant lymphopenia (median lymphocyte count, 700 per cubic millimeter). The median platelet count was 75,500 per cubic millimeter. Seven patients had diarrhea. In all patients, there were marked abnormalities on chest radiography. There was no definitive evidence of human-to-human transmission. Eight patients died, one patient has recovered, and one is recovering.
Conclusions: Influenza A (H5N1) infection, characterized by fever, respiratory symptoms, and lymphopenia, carries a high risk of death. Although in all 10 cases the infection appears to have been acquired directly from infected poultry, the potential exists for genetic reassortment with human influenzaviruses and the evolution of human-to-human transmission. Containment of influenza A (H5N1) in poultry throughout Asia is therefore urgently required.
Copyright 2004 Massachusetts Medical Society
Comment in
- Crossing the species barrier--one small step to man, one giant leap to mankind.
Klempner MS, Shapiro DS. Klempner MS, et al. N Engl J Med. 2004 Mar 18;350(12):1171-2. doi: 10.1056/NEJMp048039. Epub 2004 Feb 25. N Engl J Med. 2004. PMID: 14985471 No abstract available.
Similar articles
- Probable person-to-person transmission of avian influenza A (H5N1).
Ungchusak K, Auewarakul P, Dowell SF, Kitphati R, Auwanit W, Puthavathana P, Uiprasertkul M, Boonnak K, Pittayawonganon C, Cox NJ, Zaki SR, Thawatsupha P, Chittaganpitch M, Khontong R, Simmerman JM, Chunsutthiwat S. Ungchusak K, et al. N Engl J Med. 2005 Jan 27;352(4):333-40. doi: 10.1056/NEJMoa044021. Epub 2005 Jan 24. N Engl J Med. 2005. PMID: 15668219 - Genetic analysis of avian influenza A viruses isolated from domestic waterfowl in live-bird markets of Hanoi, Vietnam, preceding fatal H5N1 human infections in 2004.
Jadhao SJ, Nguyen DC, Uyeki TM, Shaw M, Maines T, Rowe T, Smith C, Huynh LP, Nghiem HK, Nguyen DH, Nguyen HK, Nguyen HH, Hoang LT, Nguyen T, Phuong LS, Klimov A, Tumpey TM, Cox NJ, Donis RO, Matsuoka Y, Katz JM. Jadhao SJ, et al. Arch Virol. 2009;154(8):1249-61. doi: 10.1007/s00705-009-0429-2. Epub 2009 Jul 4. Arch Virol. 2009. PMID: 19578928 - Human disease from influenza A (H5N1), Thailand, 2004.
Chotpitayasunondh T, Ungchusak K, Hanshaoworakul W, Chunsuthiwat S, Sawanpanyalert P, Kijphati R, Lochindarat S, Srisan P, Suwan P, Osotthanakorn Y, Anantasetagoon T, Kanjanawasri S, Tanupattarachai S, Weerakul J, Chaiwirattana R, Maneerattanaporn M, Poolsavathitikool R, Chokephaibulkit K, Apisarnthanarak A, Dowell SF. Chotpitayasunondh T, et al. Emerg Infect Dis. 2005 Feb;11(2):201-9. doi: 10.3201/eid1102.041061. Emerg Infect Dis. 2005. PMID: 15752436 Free PMC article. - [H5N1 avian influenza].
Calza L, Manfredi R, Chiodo F. Calza L, et al. Recenti Prog Med. 2005 Nov;96(11):523-34. Recenti Prog Med. 2005. PMID: 16499158 Review. Italian. - [Influenza type A (H5N1) virus infection].
Engin A. Engin A. Mikrobiyol Bul. 2007 Jul;41(3):485-94. Mikrobiyol Bul. 2007. PMID: 17933264 Review. Turkish.
Cited by
- Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry.
Stearns K, Lampe G, Hanan R, Marcink T, Niewiesk S, Sternberg SH, Greninger AL, Porotto M, Moscona A. Stearns K, et al. mBio. 2024 Nov 13;15(11):e0232724. doi: 10.1128/mbio.02327-24. Epub 2024 Oct 9. mBio. 2024. PMID: 39382296 Free PMC article. - Safety analysis of Oseltamivir and Baloxavir Marboxil after market approval: a pharmacovigilance study based on the FDA adverse event reporting system.
Li Y, Wang X, Liao Y, Zeng Y, Lin W, Zhuang W. Li Y, et al. BMC Infect Dis. 2024 May 9;24(1):446. doi: 10.1186/s12879-024-09339-4. BMC Infect Dis. 2024. PMID: 38724914 Free PMC article. - Comparative Pathology of Animal Models for Influenza A Virus Infection.
Kirk NM, Liang Y, Ly H. Kirk NM, et al. Pathogens. 2023 Dec 29;13(1):35. doi: 10.3390/pathogens13010035. Pathogens. 2023. PMID: 38251342 Free PMC article. Review. - Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts.
Abdelwhab EM, Mettenleiter TC. Abdelwhab EM, et al. Viruses. 2023 Apr 16;15(4):980. doi: 10.3390/v15040980. Viruses. 2023. PMID: 37112960 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical